Hepatic and renal cytochrome P-450s in spontaneously hypertensive rats

• Published in: Biochimica et biophysica acta Vol. 1074; no. 1; pp. 209 - 213
• Main Authors: Imaoka, Susumu, Funae, Yoshihiko
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24.05.1991; Elsevier
• Subjects: Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blotting, Western; Cardiology. Vascular system; Cytochrome P-450; Cytochrome P-450 Enzyme System - metabolism; Experimental diseases; Hydroxylation; Hypertension; Hypertension - enzymology; Isoenzymes - metabolism; Kidney - enzymology; Male; Medical sciences; Microsomes - enzymology; Microsomes, Liver - enzymology; Rat hepatic microsome; Rat renal microsome; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Testosterone - metabolism; Western blotting; Hypertension; Rat hepatic microsome; Western blotting; Cytochrome P-450; Rat renal microsome; Animal model; Hemoprotein; Rat; Cytochrome P450; Liver; Rodentia; Microsome; Kidney; Vertebrata; Mammalia; Enzymatic activity; Immunoblotting assay; Quantitative analysis

The differences in the levels of cytochrome P-450s in hepatic and renal microsomes between spontaneously hypertensive rats (SHR) and normotensive control rats (Wistar Kyoto rats, WKY) were investigated by Western blotting with a specific antibody. Differences in the metabolic activity of the microso...