Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

• Published in: Nature communications Vol. 4; no. 1; p. 2712
• Main Authors: Kajimoto, Taketoshi, Okada, Taro, Miya, Satoshi, Zhang, Lifang, Nakamura, Shun-ichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.11.2013; Nature Publishing Group
• Subjects: 631/80/313/1776; 631/80/86; Adsorption; Bacterial Proteins - metabolism; Cell Membrane - metabolism; Endosomes - metabolism; Exosomes - metabolism; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins - metabolism; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humanities and Social Sciences; Humans; Luminescent Proteins - metabolism; Lysophospholipids - metabolism; Lysosomes - metabolism; multidisciplinary; Protein Transport; Receptors, G-Protein-Coupled - metabolism; Receptors, Lysosphingolipid - metabolism; RNA, Small Interfering - metabolism; Science; Science (multidisciplinary); Signal Transduction; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Tetraspanin 30 - metabolism

During late endosome maturation, cargo molecules are sorted into intralumenal vesicles (ILVs) of multivesicular endosomes (MVEs), and are either delivered to lysosomes for degradation or fused with the plasma membranes for exosome release. The mechanism underlying formation of exosomal ILVs and carg...