Dietary Interactions Influence the Effects of Bovine Folate-Binding Protein on the Bioavailability of Tetrahydrofolates in Rats

• Published in: The Journal of nutrition Vol. 133; no. 2; pp. 489 - 495
• Main Authors: Jones, Martina L., Nixon, Peter F., Treloar, Tony
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.02.2003; American Institute of Nutrition; American Society for Nutritional Sciences
• Subjects: 5-formyltetrahydrofolate; 5-methyltetrahydrofolate; Animals; Babies; bioavailability; Biological and medical sciences; Biological Availability; Carrier Proteins - administration & dosage; Carrier Proteins - pharmacology; casein; Cattle; Diet; dietary interactions; Feeding. Feeding behavior; Folate Receptors, GPI-Anchored; folate-binding protein; folate-binding proteins; folic acid; foods; Fundamental and applied biological sciences. Psychology; Intestinal Absorption; Iron; Kidney - metabolism; Leucovorin - blood; Leucovorin - pharmacokinetics; lipids; Liver - metabolism; Male; milk; mothers; neonates; Nutrition; Proteins; Rats; Rats, Wistar; Receptors, Cell Surface; Tetrahydrofolates - blood; Tetrahydrofolates - pharmacokinetics; Tissue Distribution; Toxicity; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; whey; whey protein; RBP; 5-methyltetrahydrofolate; 5-CH3H4folate; M-FBP; LA-WPC; 5-CH3H4[3H]folate; WPC; L-WPC; 5-HCOH4folate; H4folate; folate-binding protein; FR-β; FR-α; dietary interactions; bioavailability; D-WPC; FBP; LG-WPC; 5-formyltetrahydrofolate; Bovine; Rat; Rodentia; Animal origin; Molecular interaction; Bioavailability; Folic acid; Folate; Feeding; Binding protein; Vertebrata; Mammalia; Diet; Animal; Artiodactyla; Ungulata

The newborns of mammals have a high folate demand, yet obtain adequate folate nutrition solely from their mothers' milk despite its low folate content. Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of th...