Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder

• Published in: Bipolar disorders Vol. 17; no. 4; pp. 403 - 408
• Main Authors: Ramos, Eliana Marisa, Gillis, Tammy, Mysore, Jayalakshmi S, Lee, Jong-Min, Alonso, Isabel, Gusella, James F, Smoller, Jordan W, Sklar, Pamela, MacDonald, Marcy E, Perlis, Roy H
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.06.2015
• Subjects: Adult; Alleles; Amyotrophic Lateral Sclerosis - genetics; bipolar disorder; Bipolar Disorder - genetics; depression; Depressive Disorder, Major - genetics; Female; Genotype; Humans; Huntingtin Protein; Huntington Disease - diagnosis; Huntington Disease - genetics; Huntington's disease; Male; Middle Aged; Nerve Tissue Proteins - genetics; neurodegenerative disease; Penetrance; polyglutamine expansion; Prevalence; Statistics as Topic; trinucleotide repeat; Trinucleotide Repeats - genetics; bipolar disorder; neurodegenerative disease; depression; trinucleotide repeat; Huntington's disease; polyglutamine expansion

Objectives Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTT CAG repeat...