Pharmacokinetics of Single Dose Lidocaine and Epinephrine Following Iontophoresis of the Tympanic Membrane in a Double-Blinded Randomized Trial

• Published in: Otology & neurotology Vol. 42; no. 7; p. 1095
• Main Authors: England, Laura J, Syms, 3rd, Charles A, York, Christopher
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: Adult; Anesthetics, Local; Double-Blind Method; Epinephrine; Humans; Iontophoresis; Lidocaine; Tympanic Membrane

To evaluate local and systemic safety of bilateral iontophoretic administration of lidocaine with epinephrine or lidocaine alone to the tympanic membrane (TM). A randomized, double-blind, two-arm study was conducted at a single center. Healthy adults were randomized to bilateral iontophoretic treatm...