Estimating the reliability of repeatedly measured endpoints based on linear mixed-effects models. A tutorial

• Published in: Pharmaceutical statistics : the journal of the pharmaceutical industry Vol. 15; no. 6; pp. 486 - 493
• Main Authors: Van der Elst, Wim, Molenberghs, Geert, Hilgers, Ralf-Dieter, Verbeke, Geert, Heussen, Nicole
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2016; Wiley Subscription Services, Inc
• Subjects: Confidence Intervals; Endpoint Determination; Humans; intra-class correlation; Linear Models; Models, Statistical; Outcome Assessment (Health Care) - methods; Reproducibility of Results; Research Design; test-retest reliability; within-cluster correlation; within-cluster correlation; intra-class correlation; test-retest reliability

There are various settings in which researchers are interested in the assessment of the correlation between repeated measurements that are taken within the same subject (i.e., reliability). For example, the same rating scale may be used to assess the symptom severity of the same patients by multiple...