Interpreting success or failure of peanut oral immunotherapy

• Published in: The Journal of clinical investigation Vol. 132; no. 2
• Main Authors: Cao, Shijie, Nagler, Cathryn R.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 18.01.2022
• Subjects: Administration, Oral; Arachis; Desensitization, Immunologic; Humans; Peanut Hypersensitivity - therapy; Th2 Cells

Peanut oral immunotherapy (OIT) was recently approved by the US FDA. However, not all patients respond to OIT, and there is a high likelihood of regaining sensitization to peanuts after cessation of treatment. It is important, therefore, to identify biomarkers that impact and predict OIT outcomes. I...