Heparin-Free Extracorporeal Life Support Using Tethered Liquid Perfluorocarbon: A Feasibility and Efficacy Study

• Published in: ASAIO journal (1992) Vol. 66; no. 7; p. 809
• Main Authors: Roberts, Teryn R, Harea, George T, Singha, Priyadarshini, Sieck, Kyle N, Beely, Brendan M, Wendorff, Daniel S, Choi, Jae Hyek, Ande, Sreedevi, Handa, Hitesh, Batchinsky, Andriy I
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Animals; Anticoagulants - pharmacology; Blood Coagulation - drug effects; Catheters, Indwelling; Extracorporeal Membrane Oxygenation - adverse effects; Extracorporeal Membrane Oxygenation - instrumentation; Extracorporeal Membrane Oxygenation - methods; Feasibility Studies; Fluorocarbons - pharmacology; Hemodynamics - drug effects; Swine; Thrombosis - etiology; Thrombosis - prevention & control

Coagulation management is the leading challenge during extracorporeal life support (ECLS) due to shear stress and foreign-surface-induced coagulation disturbance during circulation. A nonadhesive, liquid-infused coating called tethered liquid perfluorocarbon (TLP) was developed to prevent adhesion o...