Heparin-Free Extracorporeal Life Support Using Tethered Liquid Perfluorocarbon: A Feasibility and Efficacy Study
Coagulation management is the leading challenge during extracorporeal life support (ECLS) due to shear stress and foreign-surface-induced coagulation disturbance during circulation. A nonadhesive, liquid-infused coating called tethered liquid perfluorocarbon (TLP) was developed to prevent adhesion o...
Saved in:
Published in | ASAIO journal (1992) Vol. 66; no. 7; p. 809 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.07.2020
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Coagulation management is the leading challenge during extracorporeal life support (ECLS) due to shear stress and foreign-surface-induced coagulation disturbance during circulation. A nonadhesive, liquid-infused coating called tethered liquid perfluorocarbon (TLP) was developed to prevent adhesion of blood on medical materials. We investigated the novel application of TLP to commercial ECLS circuits compared with standard heparin-coated circuits in vivo in anesthetized swine for 6 hours veno-venous ECLS (1 L/min blood flow) without systemic anticoagulation (n = 3/group). We hypothesized that TLP coating permits heparin-free circulation without untoward effects while reducing thrombus deposition compared with controls. Vital signs, respiration, gas transfer, coagulation, and histology were assessed. Scanning electron microscopy (SEM), elemental mapping, and digital imaging were used to assess thrombus deposition after circulation. There were no group differences in vitals, gas exchange, coagulation, and histology. In both groups, ECLS enabled a decrease in minute volume and end-tidal CO2, with concomitant increase in pH (p < 0.05). Scanning electron microscopy and digital imaging revealed significant thrombus on heparin-coated membranes, which was reduced or absent on TLP-coated materials. Tethered liquid perfluorocarbon permitted heparin-free ECLS without altering device performance and prevented thrombus deposition versus immobilized heparin. Pending multiday in vivo testing, TLP is a promising biomaterial solution to eliminate anticoagulation requirements during ECLS. |
---|---|
AbstractList | Coagulation management is the leading challenge during extracorporeal life support (ECLS) due to shear stress and foreign-surface-induced coagulation disturbance during circulation. A nonadhesive, liquid-infused coating called tethered liquid perfluorocarbon (TLP) was developed to prevent adhesion of blood on medical materials. We investigated the novel application of TLP to commercial ECLS circuits compared with standard heparin-coated circuits in vivo in anesthetized swine for 6 hours veno-venous ECLS (1 L/min blood flow) without systemic anticoagulation (n = 3/group). We hypothesized that TLP coating permits heparin-free circulation without untoward effects while reducing thrombus deposition compared with controls. Vital signs, respiration, gas transfer, coagulation, and histology were assessed. Scanning electron microscopy (SEM), elemental mapping, and digital imaging were used to assess thrombus deposition after circulation. There were no group differences in vitals, gas exchange, coagulation, and histology. In both groups, ECLS enabled a decrease in minute volume and end-tidal CO2, with concomitant increase in pH (p < 0.05). Scanning electron microscopy and digital imaging revealed significant thrombus on heparin-coated membranes, which was reduced or absent on TLP-coated materials. Tethered liquid perfluorocarbon permitted heparin-free ECLS without altering device performance and prevented thrombus deposition versus immobilized heparin. Pending multiday in vivo testing, TLP is a promising biomaterial solution to eliminate anticoagulation requirements during ECLS. |
Author | Harea, George T Batchinsky, Andriy I Sieck, Kyle N Wendorff, Daniel S Choi, Jae Hyek Beely, Brendan M Singha, Priyadarshini Ande, Sreedevi Roberts, Teryn R Handa, Hitesh |
Author_xml | – sequence: 1 givenname: Teryn R orcidid: 0000-0002-2460-6432 surname: Roberts fullname: Roberts, Teryn R organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 2 givenname: George T orcidid: 0000-0002-4887-3471 surname: Harea fullname: Harea, George T organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 3 givenname: Priyadarshini orcidid: 0000-0001-7370-8980 surname: Singha fullname: Singha, Priyadarshini organization: College of Engineering, University of Georgia, Athens, Georgia – sequence: 4 givenname: Kyle N surname: Sieck fullname: Sieck, Kyle N organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 5 givenname: Brendan M orcidid: 0000-0001-9442-9462 surname: Beely fullname: Beely, Brendan M organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 6 givenname: Daniel S surname: Wendorff fullname: Wendorff, Daniel S organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 7 givenname: Jae Hyek surname: Choi fullname: Choi, Jae Hyek organization: From the The Geneva Foundation, Tacoma, Washington – sequence: 8 givenname: Sreedevi surname: Ande fullname: Ande, Sreedevi organization: School of Mathematics, Science and Engineering, University of the Incarnate Word, San Antonio, Texas – sequence: 9 givenname: Hitesh surname: Handa fullname: Handa, Hitesh organization: College of Engineering, University of Georgia, Athens, Georgia – sequence: 10 givenname: Andriy I surname: Batchinsky fullname: Batchinsky, Andriy I organization: From the The Geneva Foundation, Tacoma, Washington |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31453831$$D View this record in MEDLINE/PubMed |
BookMark | eNpNT9tKw0AUXESxF_0Dkf2B1L1km8S3UBorRBSagm_lbPasrqRJ3CRg_t6ACs7LMDMwzCzIed3USMgNZyvOkujuKS1W7B84U-qMzLmScZCE8nVGFl33MflKSn5JZpKHUyT5nLQ7bMG7Osg8It1-9R7KxreNR6ho7izS_dBOsqeHztVvtMD-HT2aKfscnKEv6G01NL4pweumvqcpzRA6p13l-pFCbejWWldCOdJ9P5jxilxYqDq8_uUlOWTbYrML8ueHx02aB-U0TQVWMBaBZUqHLDEJ6ARFyTEOGcYqhliERiTMSuDIUHGN8RqFVOuIS22YBrEktz-97aBPaI6tdyfw4_HvuvgGQYpc-w |
CitedBy_id | crossref_primary_10_1002_adhm_202201360 crossref_primary_10_1016_j_colsurfb_2020_110986 crossref_primary_10_1097_MAT_0000000000001292 crossref_primary_10_1021_acsbiomaterials_2c00492 crossref_primary_10_1002_advs_202207455 crossref_primary_10_1002_jbm_b_35202 crossref_primary_10_21769_BioProtoc_4814 crossref_primary_10_1097_MAT_0000000000002017 crossref_primary_10_1097_MAT_0000000000002127 crossref_primary_10_1016_j_memsci_2022_120363 crossref_primary_10_1021_acsbiomaterials_1c00758 crossref_primary_10_3390_jcm11175147 crossref_primary_10_1002_admi_202102214 crossref_primary_10_1177_02676591221095469 crossref_primary_10_1039_D3TB00471F crossref_primary_10_3389_fbioe_2023_1115254 crossref_primary_10_1016_j_actbio_2022_09_003 crossref_primary_10_1161_ATVBAHA_122_318238 crossref_primary_10_1016_j_bioadv_2022_212824 crossref_primary_10_1021_acsami_3c13462 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/MAT.0000000000001055 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1538-943X |
ExternalDocumentID | 31453831 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Journal Article |
GroupedDBID | --- .-D .55 .GJ .XZ .Z2 0R~ 23N 3O- 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS AAAAV AAHPQ AAIQE AAJCS AAMTA AARTV AASCR AAYEP ABASU ABBUW ABDIG ABJNI ABVCZ ABXVJ ABZAD ACDDN ACEWG ACGFO ACGFS ACILI ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AEBDS AEETU AENEX AFDTB AFEXH AFFNX AFUWQ AGINI AHQNM AHRYX AHVBC AI. AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F2K F2L F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ JF9 JG8 JK3 JK8 K8S KD2 KMI L-C N9A NPM N~M O9- OAG OAH OCUKA ODA ODMTH OHYEH OK1 OL1 OLG OLV OLW OLZ OPUJH ORVUJ OUVQU OVD OVDNE OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ S4R S4S T8P TEORI TSPGW V2I VH1 VVN W3M WH7 WOQ WOW X3V X3W X7M XXN XYM YFH ZFV ZGI ZXP ZZMQN |
ID | FETCH-LOGICAL-c4535-f2007af05b409d9ab9e2c1e840e858a824d290f3a1e0e51be86e2356713bd0ba2 |
IngestDate | Sat Sep 28 08:36:07 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c4535-f2007af05b409d9ab9e2c1e840e858a824d290f3a1e0e51be86e2356713bd0ba2 |
ORCID | 0000-0002-2460-6432 0000-0001-9442-9462 0000-0002-4887-3471 0000-0001-7370-8980 |
OpenAccessLink | https://doi.org/10.1097/mat.0000000000001055 |
PMID | 31453831 |
ParticipantIDs | pubmed_primary_31453831 |
PublicationCentury | 2000 |
PublicationDate | 2020-07-00 |
PublicationDateYYYYMMDD | 2020-07-01 |
PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-00 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | ASAIO journal (1992) |
PublicationTitleAlternate | ASAIO J |
PublicationYear | 2020 |
SSID | ssj0015331 |
Score | 2.397834 |
Snippet | Coagulation management is the leading challenge during extracorporeal life support (ECLS) due to shear stress and foreign-surface-induced coagulation... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 809 |
SubjectTerms | Animals Anticoagulants - pharmacology Blood Coagulation - drug effects Catheters, Indwelling Extracorporeal Membrane Oxygenation - adverse effects Extracorporeal Membrane Oxygenation - instrumentation Extracorporeal Membrane Oxygenation - methods Feasibility Studies Fluorocarbons - pharmacology Hemodynamics - drug effects Swine Thrombosis - etiology Thrombosis - prevention & control |
Title | Heparin-Free Extracorporeal Life Support Using Tethered Liquid Perfluorocarbon: A Feasibility and Efficacy Study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/31453831 |
Volume | 66 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nj9MwELW6IK32gvj-Rj5wqwKO4zgJtwh1VWC7ILUr7W1l12Mp0pItUStRfg8_lHHsNKEsCOghquIqdT2v4_H4-Q0hL6Xh2hiZRDxLDS5Q4jTSBQZywsmHJSYDId1p5NmpnJ6J9-fp-Wj0fcBa2qz1q-W3a8-V_I9V8R7a1Z2S_QfL7h6KN_A92hevaGG8_pWNp-BqCNbRcQMwnnxdN-jenDCxEws-qSyMXc1OjK_HnhiwaA_3YoR5Un3ZVMax3-3l5gqnMNVoT_EoxxgTBsasV2aaOI0JVxN-vhOi7URr5-W7jzvpCSf4VBR8kFnwpG1PQ4JmW_fcxKnCLvYZ-Z6oPcdu-h2oT021VUY5knVd9c3gvfeH7SWETaSQscDlacduxQln4GVFWwh454Z98ZUAt2zgU_NWP-FXX-81hGflwmtQhpcr-Dn8OI7d6nNr_yQW-L1-zvlz654Cd9d0QA6y3HnRU5cRCjtVGC7H3ZHMInt9XXeOyGH3iL3FSxvELG6TW2H1QUsPpTtkBPVdcjgL_Ip7ZDVEFP0ZUdQhigZE0RZRtEMU9Yiie4h6Q0s6wBNFPNEOT7TF031ydjxZvJ1GoSZHtMRfkEbW5baVZakWrDCF0gXwZQy5YJCnucq5MLxgNlExMEhjDbkEnqQyixNtmFb8AblRX9XwiFCWFRrnYs1sbkUihTY2ZiCTpeWxzCR7TB76sbpYeeGVi24Un_y25Sk56hH3jNy0-E-H5xg2rvWL1m4_ACUXaYw |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heparin-Free+Extracorporeal+Life+Support+Using+Tethered+Liquid+Perfluorocarbon%3A+A+Feasibility+and+Efficacy+Study&rft.jtitle=ASAIO+journal+%281992%29&rft.au=Roberts%2C+Teryn+R&rft.au=Harea%2C+George+T&rft.au=Singha%2C+Priyadarshini&rft.au=Sieck%2C+Kyle+N&rft.date=2020-07-01&rft.eissn=1538-943X&rft.volume=66&rft.issue=7&rft.spage=809&rft_id=info:doi/10.1097%2FMAT.0000000000001055&rft_id=info%3Apmid%2F31453831&rft_id=info%3Apmid%2F31453831&rft.externalDocID=31453831 |