Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test

• Published in: Critical care medicine Vol. 49; no. 10; p. 1651
• Main Authors: Tsalik, Ephraim L, Henao, Ricardo, Montgomery, Jesse L, Nawrocki, Jeff W, Aydin, Mert, Lydon, Emily C, Ko, Emily R, Petzold, Elizabeth, Nicholson, Bradly P, Cairns, Charles B, Glickman, Seth W, Quackenbush, Eugenia, Kingsmore, Stephen F, Jaehne, Anja K, Rivers, Emanuel P, Langley, Raymond J, Fowler, Vance G, McClain, Micah T, Crisp, Robert J, Ginsburg, Geoffrey S, Burke, Thomas W, Hemmert, Andrew C, Woods, Christopher W
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Adult; Bacterial Infections - diagnosis; Bacterial Infections - genetics; Biomarkers - analysis; Biomarkers - blood; Clinical Laboratory Techniques - methods; Clinical Laboratory Techniques - standards; Clinical Laboratory Techniques - statistics & numerical data; Emergency Service, Hospital - organization & administration; Emergency Service, Hospital - statistics & numerical data; Female; Humans; Male; Middle Aged; Transcriptome; Virus Diseases - diagnosis; Virus Diseases - genetics

Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and validate a first-in-class host response bacterial/viral test. Subjects were recruited from 2006 t...