SLC45A2: a novel malignant melanoma-associated gene

• Published in: Human mutation Vol. 29; no. 9; pp. 1161 - 1167
• Main Authors: Fernandez, L.P, Milne, R.L, Pita, G, Avilés, J.A, Lázaro, P, Benítez, J, Ribas, G
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2008
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm - genetics; cancer; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; MATP; melanoma; Melanoma - genetics; Membrane Transport Proteins - genetics; Middle Aged; pigmentation; Pigmentation - genetics; polymorphism; Polymorphism, Single Nucleotide; risk; SLC45A2; Spain - epidemiology; susceptibility; Spain

Human pigmentation appears to be one of the strongest risk factors for malignant melanoma (MM). In humans, there is a long list of genes known to be involved in rare pigmentary disorders such as albinism. These genes explain most of the variation in pigmentation phenotypes seen in human populations,...