A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis

• Published in: Angewandte Chemie International Edition Vol. 60; no. 27; pp. 15095 - 15100
• Main Authors: Wang, Kang‐Nan, Liu, Liu‐Yi, Mao, Duo, Xu, Shidang, Tan, Cai‐Ping, Cao, Qian, Mao, Zong‐Wan, Liu, Bin
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 25.06.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Cell death; Cellular structure; Chemistry; Chemistry, Multidisciplinary; Cytoplasm; Droplets; Ferroptosis; Fluorescence; fluorescence lifetime imaging; Fluorescent indicators; lipid droplets; Lipids; Microenvironments; Monitoring; Nuclei (cytology); Peroxide; Physical Sciences; Polarity; ratiometric fluorescent probes; Reactive oxygen species; Science & Technology; ferroptosis; fluorescence lifetime imaging; ratiometric fluorescent probes; MITOCHONDRIAL POLARITY; BIOLOGY; lipid droplets; BINDING; polarity; CELL-DEATH

Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fl...