A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis

Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fl...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 60; no. 27; pp. 15095 - 15100
Main Authors Wang, Kang‐Nan, Liu, Liu‐Yi, Mao, Duo, Xu, Shidang, Tan, Cai‐Ping, Cao, Qian, Mao, Zong‐Wan, Liu, Bin
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 25.06.2021
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Cell death
Cellular structure
Chemistry
Chemistry, Multidisciplinary
Cytoplasm
Droplets
Ferroptosis
Fluorescence
fluorescence lifetime imaging
Fluorescent indicators
lipid droplets
Lipids
Microenvironments
Monitoring
Nuclei (cytology)
Peroxide
Physical Sciences
Polarity
ratiometric fluorescent probes
Reactive oxygen species
Science & Technology
ferroptosis
fluorescence lifetime imaging
ratiometric fluorescent probes
MITOCHONDRIAL POLARITY
BIOLOGY
lipid droplets
BINDING
polarity
CELL-DEATH
Online AccessGet full text

Cover

Abstract Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fluorescent probe, CQPP, for monitoring polarity changes in the cellular microenvironment. Due to the donor–acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual‐targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis‐related diseases. The first lipid droplet (LD)/nucleus dual‐targeted ratiometric fluorescence probe, CQPP, for monitoring polarity change was developed. CQPP offers ratiometric fluorescence and fluorescence lifetime imaging of LD polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model.
AbstractList Ferroptosis regulates cell death through reactive oxygen species (ROS)-associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual-targeted ratiometric fluorescent probe, CQPP, for monitoring polarity changes in the cellular microenvironment. Due to the donor-acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual-targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis-related diseases.Ferroptosis regulates cell death through reactive oxygen species (ROS)-associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual-targeted ratiometric fluorescent probe, CQPP, for monitoring polarity changes in the cellular microenvironment. Due to the donor-acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual-targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis-related diseases.
Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fluorescent probe, CQPP, for monitoring polarity changes in the cellular microenvironment. Due to the donor–acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual‐targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis‐related diseases.
Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fluorescent probe, CQPP , for monitoring polarity changes in the cellular microenvironment. Due to the donor–acceptor structure of CQPP , it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual‐targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis‐related diseases.
Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of an LD/nucleus dual‐targeted ratiometric fluorescent probe, CQPP, for monitoring polarity changes in the cellular microenvironment. Due to the donor–acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals that reflect polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model. This LD/nucleus dual‐targeted fluorescent probe shows the great potential of using fluorescence imaging to study ferroptosis and ferroptosis‐related diseases. The first lipid droplet (LD)/nucleus dual‐targeted ratiometric fluorescence probe, CQPP, for monitoring polarity change was developed. CQPP offers ratiometric fluorescence and fluorescence lifetime imaging of LD polarity variations. Using nucleus imaging as a reference, CQPP was applied to report the increase in LD polarity and the homogenization of polarity between LDs and cytoplasm in the ferroptosis model.
Author Mao, Zong‐Wan
Liu, Bin
Mao, Duo
Xu, Shidang
Tan, Cai‐Ping
Wang, Kang‐Nan
Cao, Qian
Liu, Liu‐Yi
Author_xml – sequence: 1
  givenname: Kang‐Nan
  orcidid: 0000-0002-0835-8803
  surname: Wang
  fullname: Wang, Kang‐Nan
  organization: National University of Singapore
– sequence: 2
  givenname: Liu‐Yi
  surname: Liu
  fullname: Liu, Liu‐Yi
  organization: Sun Yat-Sen University
– sequence: 3
  givenname: Duo
  surname: Mao
  fullname: Mao, Duo
  organization: National University of Singapore
– sequence: 4
  givenname: Shidang
  surname: Xu
  fullname: Xu, Shidang
  organization: National University of Singapore
– sequence: 5
  givenname: Cai‐Ping
  surname: Tan
  fullname: Tan, Cai‐Ping
  organization: Sun Yat-Sen University
– sequence: 6
  givenname: Qian
  surname: Cao
  fullname: Cao, Qian
  organization: Sun Yat-Sen University
– sequence: 7
  givenname: Zong‐Wan
  surname: Mao
  fullname: Mao, Zong‐Wan
  email: cesmzw@mail.sysu.edu.cn
  organization: Sun Yat-Sen University
– sequence: 8
  givenname: Bin
  orcidid: 0000-0002-0956-2777
  surname: Liu
  fullname: Liu, Bin
  email: cheliub@nus.edu.sg
  organization: National University of Singapore
BookMark eNqNkluLEzEUgAdZcS_66nPAF0Fac5JMJvNYultdqOvi5XlIkzNrlmlSk4zSB8Gf4G_0l5jaqrAg-pQD-b5z45xWRz54rKrHQKdAKXuuvcMpowyoAMnvVSdQM5jwpuFHJRacTxpVw3F1mtJt4ZWi8kF1zLnitZTtSfVlRq7DoKPL2-9fv71Fn1x2n5C80dmFNeboDFkMY4iYDHqD5DqGFZI-RPIqeJdDdP6GzD9of4OJOE-WbuMsOY9hM2BORHtLrkYz4JiIHX_CC4zlN4fk0sPqfq-HhI8O71n1fnHxbv5ysnz94nI-W06MqMsI0oq2lZL3ql2xBq3gVguwfQ8MDQAqsC2zhmoOlrZWKdUrI1faUskRoOdn1dN93k0MH0dMuVu7Ms8waI9hTB2rAZgQTEBBn9xBb8MYfemuUILVUvBGFkrtqc-4Cn0ybrebbhPdWsdtRymVtWgkiBJRmLu826afh9Hnoj77f7XQYk-bGFKK2HfmkC1H7YYOaLe7g253B93vOyja9I72q8BfhfbQlRtw-w-6m11dXvxxfwBAHsYl
CitedBy_id crossref_primary_10_1002_adfm_202403954
crossref_primary_10_1039_D3AY01629C
crossref_primary_10_1021_acs_analchem_2c01972
crossref_primary_10_1039_D1RA07078A
crossref_primary_10_1016_j_bios_2021_113928
crossref_primary_10_1016_j_dyepig_2022_110439
crossref_primary_10_1021_acs_analchem_2c01737
crossref_primary_10_1039_D4TB01872A
crossref_primary_10_1016_j_dyepig_2023_111137
crossref_primary_10_1016_j_cclet_2023_108912
crossref_primary_10_1016_j_microc_2025_113018
crossref_primary_10_1021_acsabm_2c00488
crossref_primary_10_1002_anie_202403029
crossref_primary_10_1002_smo_20240040
crossref_primary_10_1021_acs_analchem_2c00651
crossref_primary_10_1039_D2NJ03226K
crossref_primary_10_1002_asia_202101304
crossref_primary_10_1016_j_saa_2023_122869
crossref_primary_10_1016_j_snb_2024_136248
crossref_primary_10_1039_D2CC00795A
crossref_primary_10_1039_D4TB00357H
crossref_primary_10_3390_polym13183091
crossref_primary_10_1039_D1RA06697H
crossref_primary_10_1016_j_colsurfb_2024_114173
crossref_primary_10_1002_anie_202209248
crossref_primary_10_1039_D2AN01449A
crossref_primary_10_1002_anie_202318800
crossref_primary_10_1002_asia_202400980
crossref_primary_10_1021_acs_analchem_4c03646
crossref_primary_10_1039_D2AN00212D
crossref_primary_10_1364_AO_500531
crossref_primary_10_1016_j_snb_2022_131594
crossref_primary_10_1021_acs_analchem_2c02260
crossref_primary_10_1039_D3OB00006K
crossref_primary_10_1002_anie_202111052
crossref_primary_10_1016_j_talanta_2024_126849
crossref_primary_10_1002_ange_202422996
crossref_primary_10_3389_fchem_2022_990979
crossref_primary_10_1016_j_saa_2024_124198
crossref_primary_10_1016_j_talanta_2023_124628
crossref_primary_10_1016_j_snb_2021_130458
crossref_primary_10_2139_ssrn_4109020
crossref_primary_10_1002_EXP_20230145
crossref_primary_10_1002_adhm_202303212
crossref_primary_10_1016_j_snb_2024_137121
crossref_primary_10_1007_s00216_021_03546_7
crossref_primary_10_1021_cbmi_3c00123
crossref_primary_10_1007_s11426_021_1207_0
crossref_primary_10_1021_acs_chemrev_3c00573
crossref_primary_10_1039_D3OB01545A
crossref_primary_10_1039_D4AN00912F
crossref_primary_10_1021_cbmi_3c00128
crossref_primary_10_1016_j_talanta_2023_125169
crossref_primary_10_1002_ange_202114600
crossref_primary_10_1039_D2CS00454B
crossref_primary_10_1002_anie_202423791
crossref_primary_10_1021_acssensors_1c01206
crossref_primary_10_1007_s11307_022_01774_6
crossref_primary_10_1021_acsapm_3c01337
crossref_primary_10_1002_ange_202205043
crossref_primary_10_1021_acsmaterialslett_2c01040
crossref_primary_10_1016_j_bios_2023_115596
crossref_primary_10_1016_j_snb_2025_137306
crossref_primary_10_1016_j_talanta_2024_126028
crossref_primary_10_1021_acsbiomaterials_3c00307
crossref_primary_10_1016_j_biomaterials_2022_121680
crossref_primary_10_1039_D2SC05353E
crossref_primary_10_1016_j_dyepig_2024_112305
crossref_primary_10_1021_acs_analchem_3c05676
crossref_primary_10_1016_j_cclet_2024_109923
crossref_primary_10_1016_j_dyepig_2023_111612
crossref_primary_10_1021_acs_analchem_2c02077
crossref_primary_10_1016_j_dyepig_2023_111731
crossref_primary_10_1016_j_snb_2024_137141
crossref_primary_10_1039_D3NJ02365F
crossref_primary_10_1002_adfm_202303627
crossref_primary_10_1016_j_asems_2024_100092
crossref_primary_10_1016_j_snb_2021_131285
crossref_primary_10_1016_j_snb_2024_137027
crossref_primary_10_2139_ssrn_4064682
crossref_primary_10_1016_j_talanta_2023_124413
crossref_primary_10_1016_j_bios_2023_115243
crossref_primary_10_3390_chemosensors11010062
crossref_primary_10_1016_j_cej_2023_141651
crossref_primary_10_1016_j_trac_2023_117327
crossref_primary_10_1002_adom_202300222
crossref_primary_10_1039_D4DT02673J
crossref_primary_10_1002_ange_202403029
crossref_primary_10_1016_j_chempr_2022_03_009
crossref_primary_10_1039_D2CC07008A
crossref_primary_10_1021_acsabm_2c00177
crossref_primary_10_3390_molecules29215069
crossref_primary_10_1016_j_talanta_2023_124304
crossref_primary_10_1016_j_talanta_2023_124303
crossref_primary_10_1021_acs_analchem_4c07048
crossref_primary_10_1016_j_bios_2024_116742
crossref_primary_10_1002_ange_202117229
crossref_primary_10_1007_s11426_023_1903_1
crossref_primary_10_1021_acs_analchem_4c04572
crossref_primary_10_1002_asia_202400056
crossref_primary_10_1002_smll_202104471
crossref_primary_10_1016_j_dyepig_2022_110779
crossref_primary_10_1002_adfm_202312795
crossref_primary_10_1039_D4SC04848B
crossref_primary_10_1016_j_aca_2025_343703
crossref_primary_10_1016_j_snb_2023_134142
crossref_primary_10_1002_anie_202117229
crossref_primary_10_1039_D3TB00305A
crossref_primary_10_1021_acs_analchem_2c05789
crossref_primary_10_1093_rb_rbad109
crossref_primary_10_1021_acsomega_2c05997
crossref_primary_10_1016_j_dyepig_2022_110433
crossref_primary_10_1021_acs_analchem_4c04559
crossref_primary_10_1016_j_snb_2022_131937
crossref_primary_10_1016_j_snb_2023_134825
crossref_primary_10_3390_bios12100851
crossref_primary_10_1016_j_saa_2023_122876
crossref_primary_10_1016_j_snb_2024_135659
crossref_primary_10_1016_j_carbon_2022_10_078
crossref_primary_10_1016_j_aca_2023_341776
crossref_primary_10_1016_j_matdes_2023_111611
crossref_primary_10_1016_j_cclet_2022_07_035
crossref_primary_10_1016_j_dyepig_2023_111535
crossref_primary_10_1016_j_dyepig_2023_111655
crossref_primary_10_1002_anie_202205043
crossref_primary_10_1021_acs_analchem_2c05021
crossref_primary_10_1002_ange_202111052
crossref_primary_10_1039_D1CC05717K
crossref_primary_10_1016_j_microc_2024_111193
crossref_primary_10_1016_j_matchemphys_2022_127145
crossref_primary_10_1016_j_saa_2025_125854
crossref_primary_10_1016_j_bios_2023_115289
crossref_primary_10_1002_tcr_202200035
crossref_primary_10_1016_j_saa_2024_124701
crossref_primary_10_1002_adfm_202109929
crossref_primary_10_1002_anie_202422996
crossref_primary_10_1016_j_aca_2024_342330
crossref_primary_10_1016_j_dyepig_2022_110846
crossref_primary_10_1039_D3TC01519J
crossref_primary_10_1002_asia_202101281
crossref_primary_10_1016_j_ccr_2024_215893
crossref_primary_10_1021_acsabm_2c00415
crossref_primary_10_1021_acs_jpclett_1c03917
crossref_primary_10_1039_D3SC01537H
crossref_primary_10_1016_j_rser_2023_113926
crossref_primary_10_1016_j_ccr_2024_216181
crossref_primary_10_1016_j_trac_2024_117703
crossref_primary_10_1021_acs_analchem_1c03685
crossref_primary_10_1016_j_snb_2023_133438
crossref_primary_10_1021_acs_analchem_2c03073
crossref_primary_10_1021_acsapm_3c00421
crossref_primary_10_1016_j_dyepig_2023_111082
crossref_primary_10_1002_smll_202207823
crossref_primary_10_1016_j_cej_2023_145762
crossref_primary_10_1002_anie_202114600
crossref_primary_10_1016_j_saa_2023_122333
crossref_primary_10_1088_1361_6528_ad8580
crossref_primary_10_1016_j_saa_2023_122698
crossref_primary_10_2139_ssrn_3950156
crossref_primary_10_1002_ange_202209248
crossref_primary_10_1016_j_cej_2021_132134
crossref_primary_10_1002_chem_202401285
crossref_primary_10_1016_j_snb_2024_137089
crossref_primary_10_1016_j_talanta_2024_126452
crossref_primary_10_1002_slct_202200766
crossref_primary_10_1039_D3TB00601H
crossref_primary_10_1039_D3SC06342A
crossref_primary_10_1016_j_saa_2024_124246
crossref_primary_10_1016_j_saa_2024_125455
crossref_primary_10_1039_D1NJ04264E
crossref_primary_10_1016_j_saa_2025_126049
crossref_primary_10_1016_j_cej_2024_151810
crossref_primary_10_1016_j_aca_2025_343863
crossref_primary_10_1016_j_ccr_2024_215792
crossref_primary_10_3390_chemosensors10060233
crossref_primary_10_1016_j_bios_2023_115707
crossref_primary_10_1002_ange_202423791
crossref_primary_10_1021_acs_analchem_3c03047
crossref_primary_10_1039_D4CC01813C
crossref_primary_10_1021_acs_analchem_3c05104
crossref_primary_10_1016_j_snb_2022_132707
crossref_primary_10_1007_s11426_024_2361_x
crossref_primary_10_1016_j_snb_2025_137370
crossref_primary_10_1002_slct_202200777
crossref_primary_10_1039_D2SC00889K
crossref_primary_10_1038_s41467_024_54190_5
crossref_primary_10_1016_j_snb_2022_132267
crossref_primary_10_1016_j_saa_2024_124972
crossref_primary_10_1016_j_snb_2024_136699
crossref_primary_10_1039_D4MH00190G
crossref_primary_10_1002_adfm_202315692
crossref_primary_10_1039_D4CC02565B
crossref_primary_10_1039_D3SC00022B
crossref_primary_10_1021_acsami_4c00299
crossref_primary_10_1016_j_bmc_2024_117856
crossref_primary_10_1021_acs_analchem_2c05737
crossref_primary_10_1016_j_talanta_2024_126787
crossref_primary_10_1016_j_aca_2023_341571
crossref_primary_10_1016_j_carbpol_2023_120623
crossref_primary_10_1016_j_jhazmat_2025_137452
crossref_primary_10_1021_acs_analchem_4c05120
crossref_primary_10_1039_D2OB01681H
crossref_primary_10_1021_acs_analchem_3c00142
crossref_primary_10_1021_acs_analchem_4c00227
crossref_primary_10_1039_D3AN00551H
crossref_primary_10_1039_D2TA09462B
crossref_primary_10_1016_j_snb_2025_137264
crossref_primary_10_1016_j_inoche_2023_110915
crossref_primary_10_1021_acs_analchem_1c04286
crossref_primary_10_1016_j_snb_2023_133343
crossref_primary_10_1002_agt2_421
crossref_primary_10_6023_cjoc202203039
crossref_primary_10_1002_agt2_665
crossref_primary_10_1016_j_cej_2023_145613
crossref_primary_10_1021_acs_analchem_2c04515
crossref_primary_10_1016_j_bios_2023_115646
crossref_primary_10_3390_molecules28186511
crossref_primary_10_1021_acs_chemrev_4c00546
crossref_primary_10_1016_j_talanta_2025_127805
crossref_primary_10_1073_pnas_2321255121
crossref_primary_10_1016_j_snb_2023_134687
crossref_primary_10_1002_anbr_202100084
crossref_primary_10_1002_advs_202104885
crossref_primary_10_1039_D1OB01447A
crossref_primary_10_1016_j_matdes_2023_111714
crossref_primary_10_1039_D3SC01036H
crossref_primary_10_1016_j_saa_2023_123588
crossref_primary_10_1002_adhm_202404713
crossref_primary_10_1002_ange_202318800
crossref_primary_10_1039_D1CS01167G
crossref_primary_10_1016_j_cej_2022_140756
crossref_primary_10_1021_acs_analchem_2c01243
crossref_primary_10_1016_j_biomaterials_2023_122300
crossref_primary_10_1002_adma_202308469
crossref_primary_10_1021_acs_jmedchem_3c01652
crossref_primary_10_1016_j_snb_2024_136113
crossref_primary_10_1039_D3SC04947G
crossref_primary_10_1016_j_mtchem_2023_101678
crossref_primary_10_1016_j_cclet_2024_110191
crossref_primary_10_1016_j_snb_2022_133272
crossref_primary_10_1016_j_snb_2024_136900
crossref_primary_10_1002_smtd_202400132
crossref_primary_10_1021_acs_analchem_2c02798
crossref_primary_10_1016_j_dyepig_2022_110946
crossref_primary_10_1016_j_talanta_2025_127901
crossref_primary_10_1038_s41377_022_00873_x
crossref_primary_10_1021_acs_analchem_4c01690
crossref_primary_10_1039_D4TB01669F
crossref_primary_10_1002_advs_202408030
crossref_primary_10_1021_acs_analchem_3c03999
crossref_primary_10_1039_D3SC02450D
crossref_primary_10_1016_j_cclet_2024_110620
crossref_primary_10_1016_j_cej_2023_144061
crossref_primary_10_1016_j_saa_2023_123207
crossref_primary_10_1002_slct_202202756
crossref_primary_10_1039_D3CS00063J
Cites_doi 10.1038/nrm3699
10.1073/pnas.1917946117
10.1038/cdd.2015.54
10.1038/s41557-018-0127-3
10.1002/ange.201410645
10.1038/s41580-018-0085-z
10.1039/C7CS00774D
10.1016/j.cell.2009.11.005
10.1002/ange.201802796
10.1039/C9CC01404G
10.1038/ncb3064
10.1021/acsami.8b00278
10.1021/acs.analchem.0c00456
10.1021/jacs.9b09722
10.1038/35037710
10.1038/cdd.2015.158
10.1002/adma.201904197
10.1021/jacs.7b12817
10.1016/j.tcb.2015.10.014
10.1038/nphoton.2017.82
10.1002/anie.201410645
10.1016/j.cell.2017.09.021
10.1039/C6SC90059C
10.1021/acs.analchem.8b04079
10.1021/acs.jpclett.9b00668
10.1182/blood.2019002907
10.1016/j.ccr.2019.213144
10.1016/j.cell.2012.03.042
10.1073/pnas.1912707116
10.1038/s41592-020-0782-3
10.1002/adma.201704007
10.1073/pnas.1821022116
10.1002/lipi.19670690401
10.1021/acs.jmedchem.5b00139
10.1016/j.ccr.2019.01.004
10.1002/ange.202002422
10.1038/s41586-020-2623-z
10.1021/jm9602672
10.1007/s00018-015-2031-y
10.1039/D0OB01277G
10.1016/j.dyepig.2015.11.019
10.1039/C9SC05505C
10.1002/anie.201802796
10.1039/C6SC02500E
10.1002/anie.202002422
10.1038/nature14344
10.1016/B978-0-12-816911-7.00006-2
10.1016/j.cell.2013.12.010
10.1039/c9sc05505c
10.3892/ijmm.2018.3469
10.1039/c9cc01404g
10.1039/c6sc02500e
10.1038/NPHOTON.2017.82
10.1039/d0ob01277g
ContentType Journal Article
Copyright 2021 Wiley‐VCH GmbH
2021 Wiley-VCH GmbH.
Copyright_xml – notice: 2021 Wiley‐VCH GmbH
– notice: 2021 Wiley-VCH GmbH.
DBID AAYXX
CITATION
17B
1KM
BLEPL
DTL
EGQ
HGBXW
7TM
K9.
7X8
DOI 10.1002/anie.202104163
DatabaseName CrossRef
Web of Knowledge
Index Chemicus
Web of Science Core Collection
Science Citation Index Expanded
Web of Science Primary (SCIE, SSCI & AHCI)
Web of Science - Science Citation Index Expanded - 2021
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
Web of Science
ProQuest Health & Medical Complete (Alumni)
Nucleic Acids Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
ProQuest Health & Medical Complete (Alumni)
CrossRef

Web of Science
Database_xml – sequence: 1
  dbid: 1KM
  name: Index Chemicus
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC
  sourceTypes:
    Enrichment Source
    Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1521-3773
Edition International ed. in English
EndPage 15100
ExternalDocumentID 000654761400001
10_1002_anie_202104163
ANIE202104163
Genre article
GrantInformation_xml – fundername: Fundamental Research Funds for the Central Universities
– fundername: the Ministry of Education of China
  funderid: IRT-17R111
– fundername: National Basic Research Program of China (973 Program)
  funderid: 2015CB856301
– fundername: Guangdong Basic and Applied Basic Research Foundation
  funderid: 2019A1515110356
– fundername: National Natural Science Foundation of China
  funderid: 21837006; 91953117
– fundername: National University of Singapore
  funderid: R279-000-482-133
– fundername: Postdoctoral Research Foundation of China
  funderid: 2019M662968
– fundername: China Postdoctoral Science Foundation
  grantid: 2019M662968
– fundername: National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
  grantid: 21837006; 91953117
– fundername: Guangdong Basic and Applied Basic Research Foundation
  grantid: 2019A1515110356
– fundername: Fundamental Research Funds for the Central Universities (SYSU)
– fundername: National University of Singapore
  grantid: R279-000-482-133
– fundername: Ministry of Education of China; Ministry of Education of the People's Republic of China
  grantid: IRT-17R111
– fundername: 973 Program; National Basic Research Program of China
  grantid: 2015CB856301
GroupedDBID ---
-DZ
-~X
.3N
.GA
05W
0R~
10A
1L6
1OB
1OC
1ZS
23M
33P
3SF
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5RE
5VS
66C
6TJ
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHHS
AAHQN
AAMNL
AANLZ
AAONW
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABLJU
ABPPZ
ABPVW
ACAHQ
ACCFJ
ACCZN
ACFBH
ACGFS
ACIWK
ACNCT
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEIGN
AEIMD
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFRAH
AFWVQ
AFZJQ
AHBTC
AHMBA
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BTSUX
BY8
CS3
D-E
D-F
D0L
DCZOG
DPXWK
DR1
DR2
DRFUL
DRSTM
EBS
F00
F01
F04
F5P
G-S
G.N
GNP
GODZA
H.T
H.X
HBH
HGLYW
HHY
HHZ
HZ~
IX1
J0M
JPC
KQQ
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LYRES
M53
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OIG
P2P
P2W
P2X
P4D
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RNS
ROL
RWI
RX1
RYL
SUPJJ
TN5
UB1
UPT
UQL
V2E
VQA
W8V
W99
WBFHL
WBKPD
WH7
WIB
WIH
WIK
WJL
WOHZO
WQJ
WRC
WXSBR
WYISQ
XG1
XPP
XSW
XV2
YZZ
ZZTAW
~IA
~KM
~WT
AAYXX
ABDBF
ABJNI
AEYWJ
AGHNM
AGYGG
CITATION
17B
1KM
BLEPL
DTL
GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED
GROUPED_WOS_WEB_OF_SCIENCE
7TM
K9.
7X8
ID FETCH-LOGICAL-c4533-6d499663f89b27ed43da41dff12ec11e81d92dc0a31d09d888f8c6bad063e11f3
IEDL.DBID DR2
ISICitedReferencesCount 272
ISICitedReferencesURI https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000654761400001
ISSN 1433-7851
1521-3773
IngestDate Fri Jul 11 08:40:41 EDT 2025
Fri Jul 25 11:47:55 EDT 2025
Fri Aug 29 16:07:40 EDT 2025
Wed Jul 09 17:44:02 EDT 2025
Tue Jul 01 01:17:59 EDT 2025
Thu Apr 24 22:57:58 EDT 2025
Wed Jan 22 16:28:41 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 27
Keywords ferroptosis
fluorescence lifetime imaging
ratiometric fluorescent probes
MITOCHONDRIAL POLARITY
BIOLOGY
lipid droplets
BINDING
polarity
CELL-DEATH
Language English
LinkModel DirectLink
LogoURL https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg
MergedId FETCHMERGED-LOGICAL-c4533-6d499663f89b27ed43da41dff12ec11e81d92dc0a31d09d888f8c6bad063e11f3
Notes These authors contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-0835-8803
0000-0002-0956-2777
0000-0003-3583-8367
0000-0002-7013-3672
PMID 33835669
PQID 2542564376
PQPubID 946352
PageCount 6
ParticipantIDs proquest_miscellaneous_2511244241
webofscience_primary_000654761400001CitationCount
webofscience_primary_000654761400001
crossref_citationtrail_10_1002_anie_202104163
wiley_primary_10_1002_anie_202104163_ANIE202104163
crossref_primary_10_1002_anie_202104163
proquest_journals_2542564376
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate June 25, 2021
PublicationDateYYYYMMDD 2021-06-25
PublicationDate_xml – month: 06
  year: 2021
  text: June 25, 2021
  day: 25
PublicationDecade 2020
PublicationPlace WEINHEIM
PublicationPlace_xml – name: WEINHEIM
– name: Weinheim
PublicationTitle Angewandte Chemie International Edition
PublicationTitleAbbrev ANGEW CHEM INT EDIT
PublicationYear 2021
Publisher Wiley
Wiley Subscription Services, Inc
Publisher_xml – name: Wiley
– name: Wiley Subscription Services, Inc
References 2019; 91
2015; 58
1996; 39
2018; 140
2006; 51
2019; 31
2019; 55
2015; 520
2019; 10
2015; 72
2020; 17
2020 2020; 59 132
2017; 171
2018; 41
2020; 585
1967; 69
2016; 126
2020; 11
2019; 383
2019; 141
2012; 149
2020; 406
2018; 47
2014; 156
2020; 18
2009; 139
2000; 407
2016; 7
2013; 14
2019; 20
2020
2017; 11
2018 2018; 57 130
2020; 92
2015; 22
2014; 16
2019; 116
2020; 117
2015 2015; 54 127
2018; 30
2020; 136
2018; 10
2016; 26
2016; 23
e_1_2_6_51_1
e_1_2_6_53_1
e_1_2_6_30_1
e_1_2_6_19_2
e_1_2_6_13_1
e_1_2_6_59_1
e_1_2_6_34_1
e_1_2_6_32_2
e_1_2_6_17_1
e_1_2_6_38_2
e_1_2_6_55_2
e_1_2_6_15_2
e_1_2_6_36_2
e_1_2_6_57_2
e_1_2_6_43_1
e_1_2_6_20_2
e_1_2_6_41_2
e_1_2_6_60_2
e_1_2_6_9_1
e_1_2_6_7_2
e_1_2_6_3_2
e_1_2_6_5_2
e_1_2_6_1_1
e_1_2_6_24_2
e_1_2_6_47_2
e_1_2_6_22_2
e_1_2_6_28_2
e_1_2_6_45_1
e_1_2_6_45_2
e_1_2_6_26_1
e_1_2_6_47_1
e_1_2_6_52_1
e_1_2_6_31_2
e_1_2_6_50_1
Li L. (e_1_2_6_11_2) 2018; 41
Athar Javed M. A. (e_1_2_6_49_1) 2006; 51
e_1_2_6_18_2
e_1_2_6_35_2
e_1_2_6_58_2
e_1_2_6_10_2
e_1_2_6_33_2
e_1_2_6_12_1
e_1_2_6_31_3
e_1_2_6_16_2
e_1_2_6_39_2
e_1_2_6_54_2
e_1_2_6_56_1
e_1_2_6_14_2
e_1_2_6_37_1
e_1_2_6_61_2
e_1_2_6_42_2
e_1_2_6_21_1
e_1_2_6_40_1
e_1_2_6_8_2
e_1_2_6_29_2
e_1_2_6_4_2
e_1_2_6_6_1
e_1_2_6_25_1
e_1_2_6_48_1
e_1_2_6_23_2
e_1_2_6_2_1
e_1_2_6_44_1
e_1_2_6_27_1
e_1_2_6_46_1
Ashoka, AH (WOS:000468379300017) 2019; 10
(000654761400001.23) 2020; 132
Guo, LF (WOS:000429625400013) 2018; 10
Li, WT (WOS:000467169400004) 2019; 55
Amézqueta, S (WOS:000509536800006) 2020
Niekamp, S (WOS:000519843700001) 2020; 17
Jana, P (WOS:000553219600012) 2020; 18
Collot, M (WOS:000431095100016) 2018; 140
Xie, Y (WOS:000369726800001) 2016; 23
(000654761400001.35) 2015; 127
Jiang, L (WOS:000352027700035) 2015; 520
Li, L (WOS:000429095900063) 2018; 41
Shao, CW (WOS:000532837500013) 2020; 117
Angeli, JPF (WOS:000345777300009) 2014; 16
Li, XY (WOS:000514452400019) 2020; 11
Smith, JT (WOS:000499101100030) 2019; 116
Shen, ZY (WOS:000428348000001) 2018; 30
Suseela, YV (WOS:000424136900013) 2018; 47
Gui, RJ (WOS:000458225100004) 2019; 383
Dai, J (WOS:000354911200017) 2015; 58
Jiang, N (WOS:000350100000038) 2015; 54
Pian, Q (WOS:000404546300008) 2017; 11
Fang, XX (WOS:000458365600046) 2019; 116
Thiam, AR (WOS:000327542100011) 2013; 14
Dixon, SJ (WOS:000304453900012) 2012; 149
(000654761400001.38) 2018; 130
Yang, WS (WOS:000329912200030) 2014; 156
Jiménez-Sánchez, A (WOS:000438195200014) 2018; 57
Stockwell, BR (WOS:000412346100007) 2017; 171
Ubellacker, JM (WOS:000561030800010) 2020; 585
Athar Javed, M.A. (000654761400001.40) 2006; 51
Liu, LY (WOS:000523355600001) 2020; 59
GOUW, TH (WOS:A19679706800001) 1967; 69
Hengartner, MO (WOS:000089773900051) 2000; 407
Ma, YY (WOS:000510959500003) 2020; 406
Harapanhalli, RS (WOS:A1996VU59500014) 1996; 39
Li, HY (WOS:000498281600045) 2019; 141
Yu, YY (WOS:000558573400014) 2020; 136
Colom, A (WOS:000447828700010) 2018; 10
Olzmann, JA (WOS:000459255100007) 2019; 20
Farese, RV (WOS:000272169400008) 2009; 139
Zhou, J (WOS:000384311700002) 2016; 7
Galluzzi, L (WOS:000357599500002) 2015; 22
Wang, KN (WOS:000530658600060) 2020; 92
Liang, C (WOS:000489114400001) 2019; 31
Prokhorova, EA (WOS:000363954200009) 2015; 72
Yang, WS (WOS:000370900100002) 2016; 26
Xu, HK (WOS:000455076400070) 2019; 91
Wang, KN (WOS:000370090600012) 2016; 126
References_xml – volume: 69
  start-page: 223
  year: 1967
  end-page: 226
  publication-title: Fette Seifen Anstrichm.
– volume: 55
  start-page: 4491
  year: 2019
  end-page: 4494
  publication-title: Chem. Commun.
– volume: 520
  start-page: 57
  year: 2015
  end-page: 62
  publication-title: Nature
– volume: 156
  start-page: 317
  year: 2014
  end-page: 331
  publication-title: Cell
– volume: 171
  start-page: 273
  year: 2017
  end-page: 285
  publication-title: Cell
– volume: 54 127
  start-page: 2510 2540
  year: 2015 2015
  end-page: 2514 2544
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 20
  start-page: 137
  year: 2019
  end-page: 155
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 136
  start-page: 726
  year: 2020
  end-page: 739
  publication-title: Blood
– volume: 11
  start-page: 411
  year: 2017
  end-page: 414
  publication-title: Nat. Photonics
– volume: 139
  start-page: 855
  year: 2009
  end-page: 860
  publication-title: Cell
– volume: 11
  start-page: 1617
  year: 2020
  end-page: 1622
  publication-title: Chem. Sci.
– volume: 406
  year: 2020
  publication-title: Coord. Chem. Rev.
– volume: 22
  start-page: 1237
  year: 2015
  end-page: 1238
  publication-title: Cell Death Differ.
– volume: 149
  start-page: 1060
  year: 2012
  end-page: 1072
  publication-title: Cell
– volume: 585
  start-page: 113
  year: 2020
  end-page: 118
  publication-title: Nature
– volume: 10
  start-page: 1118
  year: 2018
  end-page: 1125
  publication-title: Nat. Chem.
– volume: 58
  start-page: 3875
  year: 2015
  end-page: 3891
  publication-title: J. Med. Chem.
– volume: 57 130
  start-page: 8891 9029
  year: 2018 2018
  end-page: 8895 9033
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 31
  year: 2019
  publication-title: Adv. Mater.
– volume: 47
  start-page: 1098
  year: 2018
  end-page: 1131
  publication-title: Chem. Soc. Rev.
– volume: 14
  start-page: 775
  year: 2013
  end-page: 786
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 10
  start-page: 2414
  year: 2019
  end-page: 2421
  publication-title: J. Phys. Chem. Lett.
– volume: 116
  start-page: 2672
  year: 2019
  end-page: 2680
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 72
  start-page: 4593
  year: 2015
  end-page: 4612
  publication-title: Cell. Mol. Life Sci.
– volume: 140
  start-page: 5401
  year: 2018
  end-page: 5411
  publication-title: J. Am. Chem. Soc.
– volume: 141
  start-page: 18301
  year: 2019
  end-page: 18307
  publication-title: J. Am. Chem. Soc.
– volume: 30
  year: 2018
  publication-title: Adv. Mater.
– volume: 383
  start-page: 82
  year: 2019
  end-page: 103
  publication-title: Coord. Chem. Rev.
– volume: 17
  start-page: 437
  year: 2020
  end-page: 441
  publication-title: Nat. Methods
– volume: 16
  start-page: 1180
  year: 2014
  end-page: 1191
  publication-title: Nat. Cell Biol.
– volume: 18
  start-page: 5608
  year: 2020
  end-page: 5616
  publication-title: Org. Biomol. Chem.
– volume: 39
  start-page: 4804
  year: 1996
  end-page: 4809
  publication-title: J. Med. Chem.
– volume: 59 132
  start-page: 9719 9806
  year: 2020 2020
  end-page: 9726 9813
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 407
  start-page: 770
  year: 2000
  end-page: 776
  publication-title: Nature
– volume: 117
  start-page: 10155
  year: 2020
  end-page: 10164
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 51
  start-page: 819
  year: 2006
  end-page: 826
  publication-title: Rom. J. Phys.
– volume: 10
  start-page: 10706
  year: 2018
  end-page: 10717
  publication-title: ACS Appl. Mater. Interfaces
– volume: 23
  start-page: 369
  year: 2016
  end-page: 379
  publication-title: Cell Death Differ.
– volume: 92
  start-page: 6631
  year: 2020
  end-page: 6636
  publication-title: Anal. Chem.
– volume: 126
  start-page: 104
  year: 2016
  end-page: 109
  publication-title: Dyes Pigm.
– volume: 7
  start-page: 6575
  year: 2016
  publication-title: Chem. Sci.
– start-page: 183
  year: 2020
  end-page: 208
– volume: 7
  start-page: 6309
  year: 2016
  end-page: 6315
  publication-title: Chem. Sci.
– volume: 116
  start-page: 24019
  year: 2019
  end-page: 24030
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 41
  start-page: 3051
  year: 2018
  end-page: 3062
  publication-title: Int. J. Mol. Med.
– volume: 26
  start-page: 165
  year: 2016
  end-page: 176
  publication-title: Trends. Cell Biol.
– volume: 91
  start-page: 977
  year: 2019
  end-page: 982
  publication-title: Anal. Chem.
– ident: e_1_2_6_19_2
  doi: 10.1038/nrm3699
– ident: e_1_2_6_26_1
  doi: 10.1073/pnas.1917946117
– ident: e_1_2_6_8_2
  doi: 10.1038/cdd.2015.54
– ident: e_1_2_6_23_2
  doi: 10.1038/s41557-018-0127-3
– ident: e_1_2_6_40_1
– ident: e_1_2_6_45_2
  doi: 10.1002/ange.201410645
– ident: e_1_2_6_15_2
  doi: 10.1038/s41580-018-0085-z
– ident: e_1_2_6_37_1
– ident: e_1_2_6_53_1
– ident: e_1_2_6_42_2
  doi: 10.1039/C7CS00774D
– ident: e_1_2_6_50_1
  doi: 10.1016/j.cell.2009.11.005
– ident: e_1_2_6_47_2
  doi: 10.1002/ange.201802796
– ident: e_1_2_6_59_1
– ident: e_1_2_6_55_2
  doi: 10.1039/C9CC01404G
– ident: e_1_2_6_35_2
  doi: 10.1038/ncb3064
– ident: e_1_2_6_54_2
  doi: 10.1021/acsami.8b00278
– ident: e_1_2_6_20_2
  doi: 10.1021/acs.analchem.0c00456
– ident: e_1_2_6_25_1
  doi: 10.1021/jacs.9b09722
– ident: e_1_2_6_60_2
  doi: 10.1038/35037710
– ident: e_1_2_6_3_2
  doi: 10.1038/cdd.2015.158
– ident: e_1_2_6_5_2
  doi: 10.1002/adma.201904197
– ident: e_1_2_6_14_2
  doi: 10.1021/jacs.7b12817
– ident: e_1_2_6_10_2
  doi: 10.1016/j.tcb.2015.10.014
– ident: e_1_2_6_33_2
  doi: 10.1038/nphoton.2017.82
– ident: e_1_2_6_9_1
– ident: e_1_2_6_45_1
  doi: 10.1002/anie.201410645
– ident: e_1_2_6_1_1
  doi: 10.1016/j.cell.2017.09.021
– ident: e_1_2_6_6_1
– ident: e_1_2_6_29_2
  doi: 10.1039/C6SC90059C
– ident: e_1_2_6_38_2
  doi: 10.1021/acs.analchem.8b04079
– ident: e_1_2_6_18_2
  doi: 10.1021/acs.jpclett.9b00668
– ident: e_1_2_6_16_2
  doi: 10.1182/blood.2019002907
– ident: e_1_2_6_41_2
  doi: 10.1016/j.ccr.2019.213144
– ident: e_1_2_6_57_2
  doi: 10.1016/j.cell.2012.03.042
– ident: e_1_2_6_32_2
  doi: 10.1073/pnas.1912707116
– ident: e_1_2_6_34_1
– ident: e_1_2_6_22_2
  doi: 10.1038/s41592-020-0782-3
– ident: e_1_2_6_36_2
  doi: 10.1002/adma.201704007
– ident: e_1_2_6_4_2
  doi: 10.1073/pnas.1821022116
– ident: e_1_2_6_48_1
  doi: 10.1002/lipi.19670690401
– ident: e_1_2_6_56_1
– ident: e_1_2_6_43_1
  doi: 10.1021/acs.jmedchem.5b00139
– ident: e_1_2_6_24_2
  doi: 10.1016/j.ccr.2019.01.004
– ident: e_1_2_6_31_3
  doi: 10.1002/ange.202002422
– ident: e_1_2_6_17_1
– ident: e_1_2_6_12_1
  doi: 10.1038/s41586-020-2623-z
– ident: e_1_2_6_2_1
– ident: e_1_2_6_30_1
– ident: e_1_2_6_51_1
  doi: 10.1021/jm9602672
– ident: e_1_2_6_27_1
– ident: e_1_2_6_61_2
  doi: 10.1007/s00018-015-2031-y
– ident: e_1_2_6_13_1
– ident: e_1_2_6_39_2
  doi: 10.1039/D0OB01277G
– ident: e_1_2_6_21_1
– ident: e_1_2_6_44_1
  doi: 10.1016/j.dyepig.2015.11.019
– ident: e_1_2_6_46_1
  doi: 10.1039/C9SC05505C
– ident: e_1_2_6_47_1
  doi: 10.1002/anie.201802796
– ident: e_1_2_6_28_2
  doi: 10.1039/C6SC02500E
– volume: 51
  start-page: 819
  year: 2006
  ident: e_1_2_6_49_1
  publication-title: Rom. J. Phys.
– volume: 41
  start-page: 3051
  year: 2018
  ident: e_1_2_6_11_2
  publication-title: Int. J. Mol. Med.
– ident: e_1_2_6_31_2
  doi: 10.1002/anie.202002422
– ident: e_1_2_6_7_2
  doi: 10.1038/nature14344
– ident: e_1_2_6_52_1
  doi: 10.1016/B978-0-12-816911-7.00006-2
– ident: e_1_2_6_58_2
  doi: 10.1016/j.cell.2013.12.010
– volume: 520
  start-page: 57
  year: 2015
  ident: WOS:000352027700035
  article-title: Ferroptosis as a p53-mediated activity during tumour suppression
  publication-title: NATURE
  doi: 10.1038/nature14344
– volume: 26
  start-page: 165
  year: 2016
  ident: WOS:000370900100002
  article-title: Ferrootosis: Death by Lipid Peroxidation
  publication-title: TRENDS IN CELL BIOLOGY
  doi: 10.1016/j.tcb.2015.10.014
– volume: 10
  start-page: 2414
  year: 2019
  ident: WOS:000468379300017
  article-title: Solvatochromic Near-Infrared Probe for Polarity Mapping of Biomembranes and Lipid Droplets in Cells under Stress
  publication-title: JOURNAL OF PHYSICAL CHEMISTRY LETTERS
  doi: 10.1021/acs.jpclett.9b00668
– volume: 136
  start-page: 726
  year: 2020
  ident: WOS:000558573400014
  article-title: Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis
  publication-title: BLOOD
  doi: 10.1182/blood.2019002907
– volume: 156
  start-page: 317
  year: 2014
  ident: WOS:000329912200030
  article-title: Regulation of Ferroptotic Cancer Cell Death by GPX4
  publication-title: CELL
  doi: 10.1016/j.cell.2013.12.010
– volume: 116
  start-page: 2672
  year: 2019
  ident: WOS:000458365600046
  article-title: Ferroptosis as a target for protection against cardiomyopathy
  publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  doi: 10.1073/pnas.1821022116
– volume: 406
  start-page: ARTN 213144
  year: 2020
  ident: WOS:000510959500003
  article-title: Simultaneous sensing of nucleic acid and associated cellular components with organic fluorescent chemsensors
  publication-title: COORDINATION CHEMISTRY REVIEWS
  doi: 10.1016/j.ccr.2019.213144
– volume: 117
  start-page: 10155
  year: 2020
  ident: WOS:000532837500013
  article-title: Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis
  publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  doi: 10.1073/pnas.1917946117
– volume: 141
  start-page: 18301
  year: 2019
  ident: WOS:000498281600045
  article-title: Ferroptosis Accompanied by •OH Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/jacs.9b09722
– volume: 11
  start-page: 1617
  year: 2020
  ident: WOS:000514452400019
  article-title: A near-infrared fluorescent probe reveals decreased mitochondrial polarity during mitophagy
  publication-title: CHEMICAL SCIENCE
  doi: 10.1039/c9sc05505c
– volume: 31
  start-page: ARTN 1904197
  year: 2019
  ident: WOS:000489114400001
  article-title: Recent Progress in Ferroptosis Inducers for Cancer Therapy
  publication-title: ADVANCED MATERIALS
  doi: 10.1002/adma.201904197
– volume: 41
  start-page: 3051
  year: 2018
  ident: WOS:000429095900063
  article-title: Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death
  publication-title: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
  doi: 10.3892/ijmm.2018.3469
– volume: 58
  start-page: 3875
  year: 2015
  ident: WOS:000354911200017
  article-title: Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/acs.jmedchem.5b00139
– volume: 30
  start-page: ARTN 1704007
  year: 2018
  ident: WOS:000428348000001
  article-title: Emerging Strategies of Cancer Therapy Based on Ferroptosis
  publication-title: ADVANCED MATERIALS
  doi: 10.1002/adma.201704007
– volume: 17
  start-page: 437
  year: 2020
  ident: WOS:000519843700001
  article-title: A 6-nm ultra-photostable DNA FluoroCube for fluorescence imaging
  publication-title: NATURE METHODS
  doi: 10.1038/s41592-020-0782-3
– volume: 14
  start-page: 775
  year: 2013
  ident: WOS:000327542100011
  article-title: The biophysics and cell biology of lipid droplets
  publication-title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
  doi: 10.1038/nrm3699
– volume: 139
  start-page: 855
  year: 2009
  ident: WOS:000272169400008
  article-title: Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
  publication-title: CELL
  doi: 10.1016/j.cell.2009.11.005
– volume: 407
  start-page: 770
  year: 2000
  ident: WOS:000089773900051
  article-title: The biochemistry of apoptosis
  publication-title: NATURE
– volume: 10
  start-page: 10706
  year: 2018
  ident: WOS:000429625400013
  article-title: Interface-Targeting Strategy Enables Two-Photon Fluorescent Lipid Droplet Probes for High-Fidelity Imaging of Turbid Tissues and Detecting Fatty Liver
  publication-title: ACS APPLIED MATERIALS & INTERFACES
  doi: 10.1021/acsami.8b00278
– volume: 116
  start-page: 24019
  year: 2019
  ident: WOS:000499101100030
  article-title: Fast fit-free analysis of fluorescence lifetime imaging via deep learning
  publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  doi: 10.1073/pnas.1912707116
– volume: 383
  start-page: 82
  year: 2019
  ident: WOS:000458225100004
  article-title: Recent advances in dual-emission ratiometric fluorescence probes for chemo/biosensing and bioimaging of biomarkers
  publication-title: COORDINATION CHEMISTRY REVIEWS
  doi: 10.1016/j.ccr.2019.01.004
– volume: 130
  start-page: 9029
  year: 2018
  ident: 000654761400001.38
  publication-title: Angew. Chem
– volume: 126
  start-page: 104
  year: 2016
  ident: WOS:000370090600012
  article-title: Two fluorescence turn-on coumarin Schiffs base chemosensors for cyanide anions
  publication-title: DYES AND PIGMENTS
  doi: 10.1016/j.dyepig.2015.11.019
– volume: 57
  start-page: 8891
  year: 2018
  ident: WOS:000438195200014
  article-title: A Multifunctional Chemical Probe for the Measurement of Local Micropolarity and Microviscosity in Mitochondria
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  doi: 10.1002/anie.201802796
– volume: 16
  start-page: 1180
  year: 2014
  ident: WOS:000345777300009
  article-title: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
  publication-title: NATURE CELL BIOLOGY
  doi: 10.1038/ncb3064
– volume: 72
  start-page: 4593
  year: 2015
  ident: WOS:000363954200009
  article-title: Role of the nucleus in apoptosis: signaling and execution
  publication-title: CELLULAR AND MOLECULAR LIFE SCIENCES
  doi: 10.1007/s00018-015-2031-y
– volume: 92
  start-page: 6631
  year: 2020
  ident: WOS:000530658600060
  article-title: Aurone Derivative Revealing the Metabolism of Lipid Droplets and Monitoring Oxidative Stress in Living Cells
  publication-title: ANALYTICAL CHEMISTRY
  doi: 10.1021/acs.analchem.0c00456
– volume: 51
  start-page: 819
  year: 2006
  ident: 000654761400001.40
  publication-title: Rom. J. Phys.
– volume: 55
  start-page: 4491
  year: 2019
  ident: WOS:000467169400004
  article-title: An interface-targeting and H2O2-activatable probe liberating AIEgen: enabling on-site imaging and dynamic movement tracking of lipid droplets
  publication-title: CHEMICAL COMMUNICATIONS
  doi: 10.1039/c9cc01404g
– volume: 22
  start-page: 1237
  year: 2015
  ident: WOS:000357599500002
  article-title: Ferroptosis in p53-dependent oncosuppression and organismal homeostasis
  publication-title: CELL DEATH AND DIFFERENTIATION
  doi: 10.1038/cdd.2015.54
– volume: 91
  start-page: 977
  year: 2019
  ident: WOS:000455076400070
  article-title: Coumarin-Based Fluorescent Probes for Super-resolution and Dynamic Tracking of Lipid Droplets
  publication-title: ANALYTICAL CHEMISTRY
  doi: 10.1021/acs.analchem.8b04079
– volume: 149
  start-page: 1060
  year: 2012
  ident: WOS:000304453900012
  article-title: Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
  publication-title: CELL
  doi: 10.1016/j.cell.2012.03.042
– start-page: 183
  year: 2020
  ident: WOS:000509536800006
  article-title: Octanol-Water Partition Constant
  publication-title: LIQUID-PHASE EXTRACTION
  doi: 10.1016/B978-0-12-816911-7.00006-2
– volume: 585
  start-page: 113
  year: 2020
  ident: WOS:000561030800010
  article-title: Lymph protects metastasizing melanoma cells from ferroptosis
  publication-title: NATURE
  doi: 10.1038/s41586-020-2623-z
– volume: 127
  start-page: 2540
  year: 2015
  ident: 000654761400001.35
  publication-title: Angew. Chem
– volume: 47
  start-page: 1098
  year: 2018
  ident: WOS:000424136900013
  article-title: Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications
  publication-title: CHEMICAL SOCIETY REVIEWS
  doi: 10.1039/C7CS00774D
– volume: 69
  start-page: 223
  year: 1967
  ident: WOS:A19679706800001
  article-title: PHYSICAL PROPERTIES OF TRIGLYCERIDES .4. DIELECTRIC CONSTANT
  publication-title: FETTE SEIFEN ANSTRICHMITTEL VERBUNDEN MIT DER ZEITSCHRIFT DIE ERNAHRUNGSINDUSTRIE
– volume: 54
  start-page: 2510
  year: 2015
  ident: WOS:000350100000038
  article-title: Ratiometric Fluorescence Imaging of Cellular Polarity: Decrease in Mitochondrial Polarity in Cancer Cells
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  doi: 10.1002/anie.201410645
– volume: 7
  start-page: 6309
  year: 2016
  ident: WOS:000384311700002
  article-title: Design principles of spectroscopic probes for biological applications
  publication-title: CHEMICAL SCIENCE
  doi: 10.1039/c6sc02500e
– volume: 11
  start-page: 411
  year: 2017
  ident: WOS:000404546300008
  article-title: Compressive hyperspectral time-resolved wide-field fluorescence lifetime imaging
  publication-title: NATURE PHOTONICS
  doi: 10.1038/NPHOTON.2017.82
– volume: 20
  start-page: 137
  year: 2019
  ident: WOS:000459255100007
  article-title: Dynamics and functions of lipid droplets
  publication-title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
  doi: 10.1038/s41580-018-0085-z
– volume: 171
  start-page: 273
  year: 2017
  ident: WOS:000412346100007
  article-title: Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
  publication-title: CELL
  doi: 10.1016/j.cell.2017.09.021
– volume: 140
  start-page: 5401
  year: 2018
  ident: WOS:000431095100016
  article-title: Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues
  publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  doi: 10.1021/jacs.7b12817
– volume: 59
  start-page: 9719
  year: 2020
  ident: WOS:000523355600001
  article-title: Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  doi: 10.1002/anie.202002422
– volume: 18
  start-page: 5608
  year: 2020
  ident: WOS:000553219600012
  article-title: Live-cell imaging of lipid droplets using solvatochromic coumarin derivatives
  publication-title: ORGANIC & BIOMOLECULAR CHEMISTRY
  doi: 10.1039/d0ob01277g
– volume: 10
  start-page: 1118
  year: 2018
  ident: WOS:000447828700010
  article-title: A fluorescent membrane tension probe
  publication-title: NATURE CHEMISTRY
  doi: 10.1038/s41557-018-0127-3
– volume: 39
  start-page: 4804
  year: 1996
  ident: WOS:A1996VU59500014
  article-title: [I-125/I-127]IodoHoechst 33342: Synthesis, DNA binding, and biodistribution
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
– volume: 23
  start-page: 369
  year: 2016
  ident: WOS:000369726800001
  article-title: Ferroptosis: process and function
  publication-title: CELL DEATH AND DIFFERENTIATION
  doi: 10.1038/cdd.2015.158
– volume: 132
  start-page: 9806
  year: 2020
  ident: 000654761400001.23
  publication-title: Angew. Chem.
SSID ssj0028806
Score 2.6935427
Snippet Ferroptosis regulates cell death through reactive oxygen species (ROS)‐associated lipid peroxide accumulation, which is expected to affect the structure and...
Ferroptosis regulates cell death through reactive oxygen species (ROS)-associated lipid peroxide accumulation, which is expected to affect the structure and...
Source Web of Science
SourceID proquest
webofscience
crossref
wiley
SourceType Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 15095
SubjectTerms Cell death
Cellular structure
Chemistry
Chemistry, Multidisciplinary
Cytoplasm
Droplets
Ferroptosis
Fluorescence
fluorescence lifetime imaging
Fluorescent indicators
lipid droplets
Lipids
Microenvironments
Monitoring
Nuclei (cytology)
Peroxide
Physical Sciences
Polarity
ratiometric fluorescent probes
Reactive oxygen species
Science & Technology
Title A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.202104163
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000654761400001
https://www.proquest.com/docview/2542564376
https://www.proquest.com/docview/2511244241
Volume 60
WOS 000654761400001
WOSCitedRecordID wos000654761400001
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1fS9xAEB_El_qitVWM1bIFoU-r2c3e5e7xuHrYQg-xCr6F7J-AqDm5JC-C0I_Qz-gncSabRE8Qxb4lZPJns7Ozv9md-Q3AnjTo9pgs5EMte1z1teJai5S7yA3dQOo4rhn4fk_7R2fq13nv_EkWv-eH6BbcaGTU9poGeKqLg0fSUMrARv8OXRbCFGiEKWCLUNFJxx8lUTl9elEUcapC37I2hvJg8fbFWekRai5MRov4tZ6AJmuQtp_u404u96tS75vbZ6yO_9O2j7DaoFM28uq0Dksu_wQfxm1RuM9wN2LH5Awjdr__--8PRb-TvWQn1MHXVJ3LsMlVNZvXLFHGsWNKN2KIjJm3HrSMyHxKQ8Eucka1sy37Mac49rJgaW7ZlCiWq4L5DEo2cXO8Ws6Ki2IDziaHp-Mj3lRw4EYhjuR9q8ifirIBqkLsrIpsqoTNMiGdEcIhWB5Ka8I0EjYcWvTGs4Hp69QicHJCZNEmLOez3G0BQ-SEzwyjWCuNj6BZ1WZmYFzcU1aGWQC87cHENPTmVGXjKvHEzDKhn5p0PzWA7538jSf2eFFyp1WIpBngRYJ-NYJFheY5gG_dZewM2m9JczerSEYQekKMFMDeU0XqXlgjQBUjRKp3WQIQbxEbN80j1oIyAFlr0iuNSEbTn4fd2fZ7bvoCK3RMcXKytwPL5bxyu4jISv21HnUP4vguPA
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BOZQLb0SgFCNV4uQ2dryb3eNq6WoL7aoqrcQtih-RqpYs2iQXpEr9CfxGfgkzdpJ2kRAIjokfie2x_Y098w3AjjSo9pgi5mMtB1wNteJai5y7xI3dSOo09Qx8R4vh_Ex9-DzorAnJFybwQ_QHbjQz_HpNE5wOpPduWEPJBRsVPNRZCFTchXsU1ttrVSc9g5RE8QwORknCKQ59x9sYy7318uv70g3YXNuO1hGs34JmD0F3Px8sTy52m1rvmm-_8Dr-V-sewYMWoLJJkKjHcMeVT2Bz2sWFewpXE3ZM-jDC9x_X3z-RATwtmeyExvgLBegybHbZLFeeKMo4dkweRwzBMQsLCJ0ksuDVULHzklH4bMver8iUva5YXlq2IJblpmLBiZLN3ApT62V1Xj2Ds9n-6XTO2yAO3CiEknxoFalUSTFCaUidVYnNlbBFIaQzQjjEy2NpTZwnwsZjiwp5MTJDnVvETk6IInkOG-WydC-AIXjCOuMk1UpjFbSx2sKMjEsHysq4iIB3Q5iZluGcAm1cZoGbWWbUqVnfqRG86_N_Ddwev8251UlE1s7xKkPVGvGiwhU6grd9Mg4GXbnkpVs2lEcQgEKYFMHObUnqP-hBoEoRJfmLlgjE32Sbts0j4oI6AulF6Q-NyCaLg_3-6eW_FHoDm_PTo8Ps8GDx8RXcp_dkNicHW7BRrxr3GgFarbf9FPwJsGcyVw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB7aFNpc0jd1m7YqBHpyYsla23tcdmOSPpYlbSA3Y70gNPWGtX0JFPIT8hvzSzrjV7KF0tIebY1kSxpJ30iabwB2hEazR7vAHysx8mWkpK8Uz30b2rFNhIrjhoHv8zw6OJYfTkYnt7z4W36IYcONRkYzX9MAPzdu74Y0lDyw0b5Dk4UwxV24J6MgIb2eHQ0EUgK1s_UvCkOfwtD3tI2B2FvPv74s3WDNtdVoHcA2K1D6EPL-39uLJ99260rt6otfaB3_p3KPYKuDp2zS6tNjuGOLJ_Bg2keFewo_JmxB1jCC9-vLqy90_Z0mTHZEPfydwnNplp7Vy1VDE6UtW5C_EUNozNrpg_YRWevTULLTglHwbMNmK7rIXpUsLwybE8dyXbLWhZKldoWp1bI8LZ_Bcbr_dXrgdyEcfC0RSPqRkWRQhS5BXYitkaHJJTfOcWE15xbR8lgYHeQhN8HYoDnuEh2p3CByspy78DlsFMvCvgCG0AnLDMJYSYVF0LJqnE60jUfSiMB54Pc9mOmO35zCbJxlLTOzyKhRs6FRPXg_yJ-3zB6_ldzuFSLrRniZoWGNaFHi_OzBuyEZO4MOXPLCLmuS4QSfECR5sHNbkYYPNhBQxoiRmmMWD_jfiE276hFtQeWBaDTpD5XIJvPD_eHp5b9kegv3F7M0-3Q4__gKNuk13ZkTo23YqFa1fY3orFJvmgH4EwydMQ8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Polarity%E2%80%90Sensitive+Ratiometric+Fluorescence+Probe+for+Monitoring+Changes+in+Lipid+Droplets+and+Nucleus+during+Ferroptosis&rft.jtitle=Angewandte+Chemie+International+Edition&rft.au=Kang%E2%80%90Nan+Wang&rft.au=Liu%E2%80%90Yi+Liu&rft.au=Mao%2C+Duo&rft.au=Xu%2C+Shidang&rft.date=2021-06-25&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=1433-7851&rft.eissn=1521-3773&rft.volume=60&rft.issue=27&rft.spage=15095&rft.epage=15100&rft_id=info:doi/10.1002%2Fanie.202104163&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1433-7851&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1433-7851&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1433-7851&client=summon