Aflibercept, a VEGF (Vascular Endothelial Growth Factor)-Trap, Reduces Vascular Permeability and Stroke-Induced Brain Swelling in Obese Mice

• Published in: Stroke (1970) Vol. 52; no. 8; pp. 2637 - 2648
• Main Authors: Kim, Il-doo, Cave, John W., Cho, Sunghee
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.08.2021
• Subjects: Angiogenesis Inhibitors - pharmacology; Angiogenesis Inhibitors - therapeutic use; Animals; Biomarkers - metabolism; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain Edema - drug therapy; Brain Edema - metabolism; Capillary Permeability - drug effects; Capillary Permeability - physiology; Diet, High-Fat - adverse effects; Female; Male; Mice; Mice, Inbred C57BL; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; Original Contributions; Receptors, Vascular Endothelial Growth Factor - therapeutic use; Recombinant Fusion Proteins - pharmacology; Recombinant Fusion Proteins - therapeutic use; Stroke - drug therapy; Stroke - metabolism; Vascular Endothelial Growth Factor A - biosynthesis; brain edema; comorbidity; stroke; vascular endothelial growth factor; obesity

Brain edema is an important underlying pathology in acute stroke, especially when comorbidities are present. VEGF (Vascular endothelial growth factor) signaling is implicated in edema. This study investigated whether obesity impacts VEGF signaling and brain edema, as well as whether VEGF inhibition...