Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein - Boettcher, Michael‐Friedrich; Heinig, Roland; Schmeck, Carsten; Kohlsdorfer, Christian; Ludwig, Matthias; Schaefer, Anja; Gelfert‐Peukert, Sabine; Wensing, Georg; Weber, Olaf (British journal of clinical pharmacology, 2012)
Keywords: Administration, Oral; Adult; Biological and medical sciences; Blood Pressure - drug effects; Cholesterol Ester Transfer Proteins - antagonists & inhibitors; Cholesterol, HDL - blood; cholesteryl ester transfer protein; Clinical Trials; concentration–effect relationship; Dose-Response Relationship, Drug; Dyslipidemias - drug therapy; Dyslipidemias - metabolism; Electrocardiography - drug effects; first in man; Heart Rate - drug effects; Humans; Hydroxyquinolines - adverse effects; Hydroxyquinolines - pharmacokinetics; Hydroxyquinolines - pharmacology; Male; Medical sciences; Middle Aged; pharmacodynamics; pharmacokinetics; Pharmacology. Drug treatments; Single-Blind Method; Young Adult; Human; Pharmacokinetic pharmacodynamic relationship; Pharmacodynamics; Toxicity; cholesteryl ester transfer protein; Single dose; Male; first in man; Biological activity; Protein; Ester; Activity concentration relation; concentration-effect relationship; Adult; Inhibitor; Safety; Pharmacokinetics