Nitric Oxide in Hypertension
Hypertension is a major risk factor for cardiovascular disease, and reduction of elevated blood pressure significantly reduces the risk of cardiovascular events. Endothelial dysfunction, which is characterized by impairment of nitric oxide (NO) bioavailability, is an important risk factor for both h...
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Published in | The journal of clinical hypertension (Greenwich, Conn.) Vol. 8; no. 12 Suppl 4; pp. 17 - 29 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Three Parklands Drive, Darien, CT 06820‐3652
Le Jacq
01.12.2006
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Subjects | |
Online Access | Get full text |
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Abstract | Hypertension is a major risk factor for cardiovascular disease, and reduction of elevated blood pressure significantly reduces the risk of cardiovascular events. Endothelial dysfunction, which is characterized by impairment of nitric oxide (NO) bioavailability, is an important risk factor for both hypertension and cardiovascular disease and may represent a major link between the conditions. Evidence suggests that NO plays a major role in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension. Mice with disruption of the gene for endothelial NO synthase have elevated blood pressure levels compared with control animals, suggesting a genetic component to the link between impaired NO bioactivity and hypertension. Clinical studies have shown that patients with hypertension have a blunted arterial vasodilatory response to infusion of endothelium‐dependent vasodilators and that inhibition of NO raises blood pressure. Impaired NO bioactivity is also implicated in arterial stiffness, a major mechanism of systolic hypertension. Clarification of the mechanisms of impaired NO bioactivity in hypertension could have important implications for the treatment of hypertension. |
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AbstractList | Hypertension is a major risk factor for cardiovascular disease, and reduction of elevated blood pressure significantly reduces the risk of cardiovascular events. Endothelial dysfunction, which is characterized by impairment of nitric oxide (NO) bioavailability, is an important risk factor for both hypertension and cardiovascular disease and may represent a major link between the conditions. Evidence suggests that NO plays a major role in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension. Mice with disruption of the gene for endothelial NO synthase have elevated blood pressure levels compared with control animals, suggesting a genetic component to the link between impaired NO bioactivity and hypertension. Clinical studies have shown that patients with hypertension have a blunted arterial vasodilatory response to infusion of endothelium‐dependent vasodilators and that inhibition of NO raises blood pressure. Impaired NO bioactivity is also implicated in arterial stiffness, a major mechanism of systolic hypertension. Clarification of the mechanisms of impaired NO bioactivity in hypertension could have important implications for the treatment of hypertension. |
Author | Hermann, Matthias Flammer, Andreas Lüscher, Thomas F. |
AuthorAffiliation | 1 From the Department of Cardiology, the Cardiovascular Center, University Hospital Zurich, Switzerland |
AuthorAffiliation_xml | – name: 1 From the Department of Cardiology, the Cardiovascular Center, University Hospital Zurich, Switzerland |
Author_xml | – sequence: 1 givenname: Matthias surname: Hermann fullname: Hermann, Matthias – sequence: 2 givenname: Andreas surname: Flammer fullname: Flammer, Andreas – sequence: 3 givenname: Thomas F. surname: Lüscher fullname: Lüscher, Thomas F. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17170603$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Animals Biological Availability Blood Pressure - drug effects Elasticity Endothelium, Vascular - physiopathology Endothelium-Dependent Relaxing Factors - pharmacology Humans Hypertension - physiopathology Nitric Oxide - pharmacokinetics Nitric Oxide - pharmacology Nitric Oxide - physiology Oxidative Stress - physiology Renin-Angiotensin System - physiology Review Paper Sympathetic Nervous System - physiopathology Vasomotor System - physiology |
Title | Nitric Oxide in Hypertension |
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