Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats
Cheng W‐C, Huang R‐Y, Chiang C‐Y, Chen J‐K, Liu C‐H, Chu C‐L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodont Res 2010; 45: 788–795. © 2010 John Wiley & Sons A/S Background and Objective: The purpose of this study was to evalua...
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Published in | Journal of periodontal research Vol. 45; no. 6; pp. 788 - 795 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Publishing Ltd
01.12.2010
Blackwell |
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Abstract | Cheng W‐C, Huang R‐Y, Chiang C‐Y, Chen J‐K, Liu C‐H, Chu C‐L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodont Res 2010; 45: 788–795. © 2010 John Wiley & Sons A/S
Background and Objective: The purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti‐inflammatory properties, on experimental periodontal destruction in rats.
Material and Methods: Osteoclast formation on maxillary palatal alveolus was induced with daily lipopolysaccharide (LPS) injections (0, 1 or 5 mg/mL) for 3 d. Five days later, the osteoclasts on bony surfaces were counted after histochemical staining for tartrate‐resistant acid phosphatase. The effect of intragastric quercetin on the osteoclast formation was evaluated in the following three groups: quercetin (75 mg/kg/d by oral feeding); LPS (5 mg/mL); and quercetin plus LPS. Moreover, the effect of quercetin on the ligature‐induced periodontitis around maxillary second and mandibular first molars was further evaluated by microcomputerized tomography (on days 0, 4, 8 and 12) and by histometry (on day 8).
Results: A dose‐dependent increase in osteoclasts occurred after LPS injections. However, quercetin (75 mg/kg) reduced the 5 mg/mL LPS‐induced osteoclasts. Using microcomputerized tomography, the bone crest levels at ligation sites were found to be significantly more apical than at the control sites on days 8 and 12; however, the apically located bone crests rebounded in rats from the quercetin‐plus‐ligation group. Histometry demonstrated significantly more coronal alveolar crest bone levels, less inflammatory cell‐infiltrated connective tissue areas and less connective tissue attachments in the ligation‐plus‐quercetin group compared with those in the ligation group.
Conclusion: As the quercetin could reduce the LPS‐induced osteoclast formation and the ligature‐enhanced periodontal inflammation and bone loss, we suggest that it may have an ameliorative effect on periodontal destruction. |
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AbstractList | BACKGROUND AND OBJECTIVEThe purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti-inflammatory properties, on experimental periodontal destruction in rats.MATERIAL AND METHODSOsteoclast formation on maxillary palatal alveolus was induced with daily lipopolysaccharide (LPS) injections (0, 1 or 5 mg/mL) for 3 d. Five days later, the osteoclasts on bony surfaces were counted after histochemical staining for tartrate-resistant acid phosphatase. The effect of intragastric quercetin on the osteoclast formation was evaluated in the following three groups: quercetin (75 mg/kg/d by oral feeding); LPS (5 mg/mL); and quercetin plus LPS. Moreover, the effect of quercetin on the ligature-induced periodontitis around maxillary second and mandibular first molars was further evaluated by microcomputerized tomography (on days 0, 4, 8 and 12) and by histometry (on day 8).RESULTSA dose-dependent increase in osteoclasts occurred after LPS injections. However, quercetin (75 mg/kg) reduced the 5 mg/mL LPS-induced osteoclasts. Using microcomputerized tomography, the bone crest levels at ligation sites were found to be significantly more apical than at the control sites on days 8 and 12; however, the apically located bone crests rebounded in rats from the quercetin-plus-ligation group. Histometry demonstrated significantly more coronal alveolar crest bone levels, less inflammatory cell-infiltrated connective tissue areas and less connective tissue attachments in the ligation-plus-quercetin group compared with those in the ligation group.CONCLUSIONAs the quercetin could reduce the LPS-induced osteoclast formation and the ligature-enhanced periodontal inflammation and bone loss, we suggest that it may have an ameliorative effect on periodontal destruction. Cheng W‐C, Huang R‐Y, Chiang C‐Y, Chen J‐K, Liu C‐H, Chu C‐L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodont Res 2010; 45: 788–795. © 2010 John Wiley & Sons A/S Background and Objective: The purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti‐inflammatory properties, on experimental periodontal destruction in rats. Material and Methods: Osteoclast formation on maxillary palatal alveolus was induced with daily lipopolysaccharide (LPS) injections (0, 1 or 5 mg/mL) for 3 d. Five days later, the osteoclasts on bony surfaces were counted after histochemical staining for tartrate‐resistant acid phosphatase. The effect of intragastric quercetin on the osteoclast formation was evaluated in the following three groups: quercetin (75 mg/kg/d by oral feeding); LPS (5 mg/mL); and quercetin plus LPS. Moreover, the effect of quercetin on the ligature‐induced periodontitis around maxillary second and mandibular first molars was further evaluated by microcomputerized tomography (on days 0, 4, 8 and 12) and by histometry (on day 8). Results: A dose‐dependent increase in osteoclasts occurred after LPS injections. However, quercetin (75 mg/kg) reduced the 5 mg/mL LPS‐induced osteoclasts. Using microcomputerized tomography, the bone crest levels at ligation sites were found to be significantly more apical than at the control sites on days 8 and 12; however, the apically located bone crests rebounded in rats from the quercetin‐plus‐ligation group. Histometry demonstrated significantly more coronal alveolar crest bone levels, less inflammatory cell‐infiltrated connective tissue areas and less connective tissue attachments in the ligation‐plus‐quercetin group compared with those in the ligation group. Conclusion: As the quercetin could reduce the LPS‐induced osteoclast formation and the ligature‐enhanced periodontal inflammation and bone loss, we suggest that it may have an ameliorative effect on periodontal destruction. The purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti-inflammatory properties, on experimental periodontal destruction in rats. Osteoclast formation on maxillary palatal alveolus was induced with daily lipopolysaccharide (LPS) injections (0, 1 or 5 mg/mL) for 3 d. Five days later, the osteoclasts on bony surfaces were counted after histochemical staining for tartrate-resistant acid phosphatase. The effect of intragastric quercetin on the osteoclast formation was evaluated in the following three groups: quercetin (75 mg/kg/d by oral feeding); LPS (5 mg/mL); and quercetin plus LPS. Moreover, the effect of quercetin on the ligature-induced periodontitis around maxillary second and mandibular first molars was further evaluated by microcomputerized tomography (on days 0, 4, 8 and 12) and by histometry (on day 8). A dose-dependent increase in osteoclasts occurred after LPS injections. However, quercetin (75 mg/kg) reduced the 5 mg/mL LPS-induced osteoclasts. Using microcomputerized tomography, the bone crest levels at ligation sites were found to be significantly more apical than at the control sites on days 8 and 12; however, the apically located bone crests rebounded in rats from the quercetin-plus-ligation group. Histometry demonstrated significantly more coronal alveolar crest bone levels, less inflammatory cell-infiltrated connective tissue areas and less connective tissue attachments in the ligation-plus-quercetin group compared with those in the ligation group. As the quercetin could reduce the LPS-induced osteoclast formation and the ligature-enhanced periodontal inflammation and bone loss, we suggest that it may have an ameliorative effect on periodontal destruction. |
Author | Huang, R.-Y. Chu, C.-L. Fu, E. Chiang, C.-Y. Liu, C.-H. Cheng, W.-C. Chen, J.-K. |
Author_xml | – sequence: 1 givenname: W.-C. surname: Cheng fullname: Cheng, W.-C. organization: Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan – sequence: 2 givenname: R.-Y. surname: Huang fullname: Huang, R.-Y. organization: Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan – sequence: 3 givenname: C.-Y. surname: Chiang fullname: Chiang, C.-Y. organization: Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan – sequence: 4 givenname: J.-K. surname: Chen fullname: Chen, J.-K. organization: Center for Nanomedicine Research, National Health Research Institutes, Miaoli, Taiwan – sequence: 5 givenname: C.-H. surname: Liu fullname: Liu, C.-H. organization: Center for Nanomedicine Research, National Health Research Institutes, Miaoli, Taiwan – sequence: 6 givenname: C.-L. surname: Chu fullname: Chu, C.-L. organization: National Health Research Institutes, Miaoli, Taiwan – sequence: 7 givenname: E. surname: Fu fullname: Fu, E. organization: Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan |
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Keywords | Periodontal disease Vertebrata Mammalia Destruction Periodontitis Rat Stomatology Animal Rodentia quercetin Inflammation |
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Snippet | Cheng W‐C, Huang R‐Y, Chiang C‐Y, Chen J‐K, Liu C‐H, Chu C‐L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in... The purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti-inflammatory properties, on experimental periodontal... BACKGROUND AND OBJECTIVEThe purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti-inflammatory properties, on... |
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SubjectTerms | Administration, Oral Alveolar Bone Loss - diagnostic imaging Alveolar Bone Loss - drug therapy Animals Antioxidants - administration & dosage Antioxidants - therapeutic use Biological and medical sciences Dentistry Dose-Response Relationship, Drug Facial bones, jaws, teeth, parodontium: diseases, semeiology inflammation Ligation Lipopolysaccharides Male Medical sciences Non tumoral diseases Osteoclasts - drug effects Otorhinolaryngology. Stomatology periodontitis Periodontitis - drug therapy quercetin Quercetin - administration & dosage Quercetin - therapeutic use Random Allocation rat Rats Rats, Sprague-Dawley X-Ray Microtomography |
Title | Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats |
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