Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection

• Published in: Transplantation Vol. 104; no. 4; p. 744
• Main Authors: van Alem, Carla M A, Schmidbauer, Martina, Rong, Song, Derlin, Katja, Schmitz, Jessica, Bräsen, Jan H, Thorenz, Anja, Chen, Rongjun, Ruben, Jurjen M, Winter, Elizabeth M, Schilperoort, Maaike, Kooijman, Sander, Lalai, Reshma A, Metselaar, Josbert M, Klemann, Christian, Meier, Martin, van Kooten, Cees, Gueler, Faikah, Rotmans, Joris I
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020
• Subjects: Allografts; Animals; Calcineurin Inhibitors - administration & dosage; Cyclosporine - administration & dosage; Disease Models, Animal; Glucocorticoids - administration & dosage; Glucocorticoids - metabolism; Graft Rejection - drug therapy; Graft Rejection - immunology; Graft Rejection - metabolism; Graft Rejection - pathology; Injections, Intravenous; Kidney - drug effects; Kidney - immunology; Kidney - metabolism; Kidney - pathology; Kidney Transplantation; Liposomes; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Nephritis - drug therapy; Nephritis - immunology; Nephritis - metabolism; Nephritis - pathology; Prednisolone - administration & dosage; Prednisolone - metabolism; Tissue Distribution

Systemic exposure to high-dose corticosteroids effectively combats acute rejection after kidney transplantation, but at the cost of substantial side effects. In this study, a murine acute renal allograft rejection model was used to investigate whether liposomal-encapsulated prednisolone (LP) facilit...