Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 3; no. 12; pp. 1 - 9
• Main Authors: Li, R, Barton, H A, Maurer, T S
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2014; Nature Publishing Group
• Subjects: Digitization; Drug dosages; Haplotypes; Liver; Original; Pharmacokinetics; Population; Studies

Physiologically based pharmacokinetic (PBPK) models are increasingly being used to provide human pharmacokinetic (PK) predictions for organic anion‐transporting polypeptide (OATP) substrates based on in vitro assay data. As a natural extension in the application of these models, in this study, we in...