Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms

• Published in: Journal of hypertension Vol. 35; no. 2; p. 205
• Main Authors: Seccia, Teresa M, Caroccia, Brasilina, Calò, Lorenzo A
• Format: Journal Article
• Language: English
• Published: England 01.02.2017
• Subjects: Albuminuria - urine; Animals; Arterioles - pathology; Biomarkers - urine; Epithelial-Mesenchymal Transition; Humans; Hypertension, Renal - pathology; Hypertension, Renal - physiopathology; Kidney Glomerulus - pathology; Kidney Tubules - pathology; Nephritis - pathology; Nephritis - physiopathology; Podocytes

Hypertensive kidney disease classically entails nephroangiosclerosis and hyalinosis with glomerular damage. However, in recent years, several evidences showed that high blood pressure also injures tubular cells, inducing epithelial-to-mesenchymal transition and tubulointerstitial fibrosis. Recently...