Metallothionein protein variants generated in rat liver as a result of DNA and RNA ethylations by the carcinogen diethylnitrosamine

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 164; no. 6; pp. 361 - 367
• Main Authors: Jauch, A., Lutz, W.K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.1986
• Subjects: Alkylation; Animals; Cysteine - metabolism; Diethylnitrosamine - toxicity; DNA - drug effects; Genetic Variation; Liver - drug effects; Liver - metabolism; Male; Metallothionein - biosynthesis; Metallothionein - genetics; Metallothionein - isolation & purification; Phenylalanine - metabolism; Rats; Rats, Inbred Strains; RNA - drug effects; Tyrosine - metabolism

Metallothionein (MT) is a protein which contains 20 cysteine residues but no aromatic amino acids. It was tested whether treatment of male rats with the hepatocarcinogen diethylnitrosamine (DENA) could ethylate nucleic acids in such a way that protein variants containing measurable amounts of aromat...