Impaired Cellular Immune Responses During the First Week of Severe Acute Influenza Infection

• Published in: The Journal of infectious diseases Vol. 222; no. 7; pp. 1235 - 1244
• Main Authors: Turner, Jackson S, Lei, Tingting, Schmitz, Aaron J, Day, Aaron, Choreño-Parra, José Alberto, Jiménez-Alvarez, Luis, Cruz-Lagunas, Alfredo, House, Stacey L, Zúñiga, Joaquín, Ellebedy, Ali H, Mudd, Philip A
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.09.2020
• Subjects: Adult; Aged; Antigens; CD8 antigen; CD8-Positive T-Lymphocytes - pathology; Enzyme-linked immunosorbent assay; Female; Flow cytometry; Humans; Immune response; Immune response (cell-mediated); Immunity, Cellular; Infections; Inflammation; Influenza; Influenza, Human - blood; Influenza, Human - immunology; Influenza, Human - pathology; Leukocyte Count; Leukocytes (mononuclear); Lymphocyte Count; Lymphocytes - pathology; Lymphocytes B; Lymphocytes T; Major and Brief Reports; Male; Mechanical ventilation; Middle Aged; Monocytes; Monocytes - pathology; Peripheral blood mononuclear cells; Prospective Studies; Respiration, Artificial; Severity of Illness Index; Ventilation; illness severity; B cell; monocyte; CD8+ T cell; Influenza; cellular immunity

Abstract Background Cellular immune responses are not well characterized during the initial days of acute symptomatic influenza infection. Methods We developed a prospective cohort of human subjects with confirmed influenza illness of varying severity who presented within a week after symptom onset....