Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

• Published in: Structure (London) Vol. 31; no. 7; pp. 801 - 811.e5
• Main Authors: Patel, Anamika, Kumar, Sanjeev, Lai, Lilin, Chakravarthy, Chennareddy, Valanparambil, Rajesh, Reddy, Elluri Seetharami, Gottimukkala, Kamalvishnu, Bajpai, Prashant, Raju, Dinesh Ravindra, Edara, Venkata Viswanadh, Davis-Gardner, Meredith E., Linderman, Susanne, Dixit, Kritika, Sharma, Pragati, Mantus, Grace, Cheedarla, Narayanaiah, Verkerke, Hans P., Frank, Filipp, Neish, Andrew S., Roback, John D., Davis, Carl W., Wrammert, Jens, Ahmed, Rafi, Suthar, Mehul S., Sharma, Amit, Murali-Krishna, Kaja, Chandele, Anmol, Ortlund, Eric A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 06.07.2023
• Subjects: Antibodies, Monoclonal; Antibodies, Neutralizing; COVID-19; cryo-EM structure; Epitopes; human monoclonal antibodies; Humans; Neutralization Tests; neutralizing antibodies; SARS-CoV-2 - genetics; SARS-CoV-2 variants; shared antibody response; COVID-19; SARS-CoV-2 variants; neutralizing antibodies; human monoclonal antibodies; cryo-EM structure; shared antibody response

Understanding the molecular features of neutralizing epitopes is important for developing vaccines/therapeutics against emerging SARS-CoV-2 variants. We describe three monoclonal antibodies (mAbs) generated from COVID-19 recovered individuals during the first wave of the pandemic in India. These mAb...