Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats
Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The anbodies occurred in association with acute lethal hepati...
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| Published in | Biochimica et biophysica acta Vol. 1158; no. 3; pp. 339 - 344 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
28.11.1993
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/0304-4165(93)90033-5 |
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| Abstract | Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The anbodies occurred in association with acute lethal hepatitis in the LEC rats in our previous study. Two-dimensional immunoblot analysis of the antigenic proteins revealed that the 56kD and 55kD proteins showed 4.2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH
2-terminal amino acid sequence analysis. These proteins were further identified by immunoblot analyses using proteins and specific antibodies. PDI was a major autoimmune antigenic protein. |
|---|---|
| AbstractList | Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The antibodies occurred in association with acute lethal hepatitis in the LEC rats in our previous study. Two-dimensional immunoblot analysis of the antigenic proteins revealed that the 56kDa and 55kDa proteins showed 4.2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH2-terminal amino acid sequence analysis. These proteins were further identified by immunoblot analyses using purified proteins and specific antibodies. PDI was a major autoimmune antigenic protein. Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The antibodies occurred in association with acute lethal hepatitis in the LEC rats in our previous study. Two-dimensional immunoblot analysis of the antigenic proteins revealed that the 56kDa and 55kDa proteins showed 4.2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH2-terminal amino acid sequence analysis. These proteins were further identified by immunoblot analyses using purified proteins and specific antibodies. PDI was a major autoimmune antigenic protein.Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The antibodies occurred in association with acute lethal hepatitis in the LEC rats in our previous study. Two-dimensional immunoblot analysis of the antigenic proteins revealed that the 56kDa and 55kDa proteins showed 4.2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH2-terminal amino acid sequence analysis. These proteins were further identified by immunoblot analyses using purified proteins and specific antibodies. PDI was a major autoimmune antigenic protein. Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal proteins, particularly to proteins with the molecular weight of 56kD and 55kD. The anbodies occurred in association with acute lethal hepatitis in the LEC rats in our previous study. Two-dimensional immunoblot analysis of the antigenic proteins revealed that the 56kD and 55kD proteins showed 4.2 and 4.0 pI values and were estimated to be protein disulfide isomerase (PDI) and calreticulin, respectively, from NH 2-terminal amino acid sequence analysis. These proteins were further identified by immunoblot analyses using proteins and specific antibodies. PDI was a major autoimmune antigenic protein. |
| Author | Yokoi, Tsuyoshi Kawaguchi, Yasuro Horiuchi, Ryuya Nagayama, Sekio Kamataki, Tetsuya Kajiwara, Rieko |
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| Cites_doi | 10.1042/bj2280635 10.1016/S0021-9258(19)41496-8 10.1177/36.8.3292644 10.1177/36.12.3192937 10.1016/S0021-9258(19)52451-6 10.1111/j.1432-1033.1989.tb21081.x 10.1016/S0021-9258(20)89624-0 10.1139/o89-104 10.1016/0006-291X(91)91938-9 10.1038/227680a0 10.1002/hep.1840050504 10.1016/S0021-9258(18)61070-1 10.1172/JCI114582 10.1021/tx00027a014 10.1016/S0021-9258(18)89644-2 10.1093/oxfordjournals.jhered.a110416 10.1002/j.1460-2075.1989.tb08530.x 10.1016/S0021-9258(19)86033-7 10.1242/jcs.91.1.61 10.1016/0006-291X(87)90817-5 10.1002/hep.1840080627 10.1002/j.1460-2075.1988.tb02896.x 10.4049/jimmunol.147.9.3031 10.1016/S0021-9258(19)43026-3 |
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| Keywords | LEC rats Calreticulin Autoimmune Autoantigen Protein isomerase Intramolecular oxidoreductases Rat Enzyme Antibody Liver Rodentia Microsome Vertebrata Isomerases Mammalia Protein disulfide-isomerase |
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| Snippet | Long Evans Cinnamon (LEC) rats, showing spontaneous hereditary hepatitis and hepatic carcinoma, were found to possess autoimmune antibodies to liver microsomal... |
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| SubjectTerms | Amino Acid Sequence Animals Antigens - immunology Antigens - isolation & purification Autoantibodies - analysis Autoantibodies - immunology Autoantigen Autoimmune Autoimmunity Autoimmunity (experimental aspects and models) Biological and medical sciences Calcium-Binding Proteins - immunology Calcium-Binding Proteins - isolation & purification Calreticulin Cell Membrane - enzymology Fundamental and applied biological sciences. Psychology Fundamental immunology Hepatitis - immunology Intracellular Membranes - enzymology Isomerases - immunology Isomerases - isolation & purification LEC rats Microsomes, Liver - enzymology Molecular Sequence Data Protein Disulfide-Isomerases Protein isomerase Rats Rats, Inbred Strains Ribonucleoproteins - immunology Ribonucleoproteins - isolation & purification |
| Title | Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats |
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