The Heme Degradation Pathway is a Promising Serum Biomarker Source for the Early Detection of Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 19; no. 3; pp. 1081 - 1091
• Main Authors: Mueller, Claudius, Zhou, Weidong, VanMeter, Amy, Heiby, Michael, Magaki, Shino, Ross, Mark M., Espina, Virginia, Schrag, Matthew, Dickson, Cindy, Liotta, Lance A., Kirsch, Wolff M.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2010
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Biomarkers; Cognition Disorders - diagnosis; Diagnosis, Differential; Female; Heme Oxygenase-1 - metabolism; Humans; Male; Mass Spectrometry; Matrix Metalloproteinase 9 - metabolism; Neuropsychological Tests; Phospholipase D - metabolism; Protein Array Analysis; Severity of Illness Index; prosaposin; phospholipase D1; heme; heme oxyengase-1; BLVR; biomarker; serum; Alzheimer's disease; complement factor H; BVR; S100A7

One of the remaining challenges in Alzheimer's disease (AD) research is the establishment of biomarkers for early disease detection. As part of a prospective study spanning a period of five years, we have collected serial serum samples from cognitively normal, mild cognitively impaired (MCI), a...