Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial

• Published in: British journal of anaesthesia : BJA Vol. 132; no. 5; pp. 857 - 866
• Main Authors: Gutierrez del Arroyo, Ana, Patel, Akshaykumar, Abbott, Tom E.F., Begum, Salma, Dias, Priyanthi, Somanath, Sameer, Middleditch, Alexander, Cleland, Stuart, Brealey, David, Pearse, Rupert M., Ackland, Gareth L., Ackland, Gareth, Martin, Tim, Fernandez, Maria, Seidu, Fatima, Pakats, Mari-Liis, Mahr, Otto, MacDonald, Neil, Santos, Filipa Dos, Garcia, Amaia Arrieta, Uddin, Ruzena, Pearse, Rupert, Subhedar, Emily, Wan, Yize, Shahid, Tasnin, Gooneratne, Mevan, Trainer, Charlotte, Griffiths, Bethan, Dunkley, Steven, May, Shaun, Walker, Sophie, Fowler, Alexander, Stephens, Timothy, Oliveira, Monica, Januszewska, Marta, Niebrzegowska, Edyta, Amaral, Vanessa, Kassam, Jamila, Young, Sophie, Ahmad, Shanaz, Whalley, Jan, Haines, Ryan, Hui, Sara, Hammond, Rob, Crane, David, Bampoe, Sohail, Stephens, Robert, Reyes, Anna, Martir, Gladys, Diaz, Chimverly, Minto, Gary, Affleck, Debbie-Claire, Werrett, Gavin, Cummins, Susan, Amber, Alan, Biffen, Andrew, Boumphrey, Stephen, Cann, Elizabeth, Eglinton, Charlotte, Jones, Elaine, Mwadeyi, Memory, Piesley, Sam, Cowan, Richard, Alderton, Julie, Reed, Fiona, Smith, Joanne, Turner, Amy, Madziva, Lorraine, Patrick, Abigail, Harris, Penny, Lang, Harry, Pickering, Anthony, O’Donovan, Catherine, Houlihan, Rebecca, Jarvis, Rosina, Shrimpton, Andrew, Farmery, Toni, Tucker, Katy, Davis, Danielle, Somanth, Sameer, Duncan, Louise, Melsom, Helen, Clark, Sarah, Kent, Melanie, Wood, Michelle, Laidlaw, Ami, Matheson-Smith, Tracy, Potts, Kathryn, Kay, Andrea, Hobson, Stefanie, Sear, John, Kapil, Vikas, Archbold, Andrew, Wilson, Matt, Ly, Dennis
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2024; Elsevier
• Subjects: Cardiovascular; major cardiac events; myocardial injury; noncardiac surgery; perioperative care; renin-angiotensin system inhibitors; major cardiac events; myocardial injury; renin-angiotensin system inhibitors; perioperative care; noncardiac surgery

Patients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml−1) experience more complications after noncardiac surgery. Individuals prescribed renin–angiotensin system (RAS) inhibitors for cardiometabolic disease are at particular risk of perioperativ...