Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis

• Published in: Journal of vascular surgery Vol. 68; no. 6; pp. 222S - 233S.e1
• Main Authors: Pfaff, Miles J., Mukhopadhyay, Subhradip, Hoofnagle, Mark, Chabasse, Christine, Sarkar, Rajabrata
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018
• Subjects: Angiogenesis; Angiogenesis Inducing Agents - pharmacology; Angiogenesis Inhibitors - pharmacology; Animals; Arteriogenesis; Benzothiazoles - pharmacology; Blood Flow Velocity; Collateral Circulation; Disease Models, Animal; Endothelial Cells - metabolism; HIF-1α; Hindlimb; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1α; Ischemia; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal - blood supply; Neovascularization; Neovascularization, Physiologic - drug effects; p53; Quinacrine - pharmacology; Regional Blood Flow; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Reperfusion Injury - physiopathology; Reperfusion Injury - prevention & control; Signal Transduction; Tissue Culture Techniques; Toluene - analogs & derivatives; Toluene - pharmacology; Tumor Suppressor Protein p53 - agonists; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; VEGF; Angiogenesis; Arteriogenesis; Hypoxia-inducible factor 1α; Ischemia; VEGF; HIF-1α; Neovascularization; Vascular endothelial growth factor; p53

The tumor suppressor protein p53 regulates angiogenesis and is a key regulatory mediator of cellular apoptosis, proliferation, and growth. p53 expression is induced in response to ischemia; however, its role in regulating ischemia-induced angiogenesis and arteriogenesis remains undefined. The object...