A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 199; no. 4; pp. 465 - 477
• Main Authors: Peters, Michael C., Ringel, Lando, Dyjack, Nathan, Herrin, Rachelle, Woodruff, Prescott G., Rios, Cydney, O’Connor, Brian, Fahy, John V., Seibold, Max A.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.02.2019
• Subjects: Adult; Asthma; Asthma - complications; Asthma - immunology; Asthma - metabolism; Biology; Case-Control Studies; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cytokines; Cytotoxicity; Dendritic cells; Dendritic Cells - metabolism; Dermatitis; Female; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; Genomes; Humans; Immunology; Inflammation; Inflammation - immunology; Inflammation - metabolism; Lymphocytes; Male; Metabolism; Middle Aged; Obesity - complications; Obesity - immunology; Obesity - metabolism; Ontology; Original; Sputum - immunology; asthma; dendritic cells; type 2; CD8 cytotoxic T cells; sputum gene expression

Type 2 (T2) inflammation drives airway dysfunction in many patients with asthma; yet, we lack a comprehensive understanding of the airway immune cell types and networks that sustain this inflammation. Moreover, defects in the airway immune system in patients with asthma without T2 inflammation are n...