Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis

• Published in: American journal of respiratory and critical care medicine Vol. 196; no. 12; pp. 1571 - 1581
• Main Authors: Ryu, Changwan, Sun, Huanxing, Gulati, Mridu, Herazo-Maya, Jose D., Chen, Yonglin, Osafo-Addo, Awo, Brandsdorfer, Caitlin, Winkler, Julia, Blaul, Christina, Faunce, Jaden, Pan, Hongyi, Woolard, Tony, Tzouvelekis, Argyrios, Antin-Ozerkis, Danielle E., Puchalski, Jonathan T., Slade, Martin, Gonzalez, Anjelica L., Bogenhagen, Daniel F., Kirillov, Varvara, Feghali-Bostwick, Carol, Gibson, Kevin, Lindell, Kathleen, Herzog, Raimund I., Dela Cruz, Charles S., Mehal, Wajahat, Kaminski, Naftali, Herzog, Erica L., Trujillo, Glenda
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.12.2017
• Subjects: Aged; Biomarkers; Clinical outcomes; Deoxyribonucleic acid; Disease-Free Survival; DNA; DNA, Mitochondrial - metabolism; Female; Fibroblasts; Fibroblasts - metabolism; Genotype & phenotype; Growth factors; Humans; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - mortality; Lung diseases; Male; Metabolism; Mitochondrial DNA; Mortality; Neutrophils; Original; Pulmonary fibrosis; Smooth muscle; interstitial lung disease; biomarkers; mechanotransduction; mitochondria

Idiopathic pulmonary fibrosis (IPF) involves the accumulation of α-smooth muscle actin-expressing myofibroblasts arising from interactions with soluble mediators such as transforming growth factor-β1 (TGF-β1) and mechanical influences such as local tissue stiffness. Whereas IPF fibroblasts are enric...