LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p/ROCK1 in nonalcoholic fatty liver disease

• Published in: Life sciences (1973) Vol. 235; p. 116829
• Main Authors: Chen, Xi, Tan, Xin-Rui, Li, Shi-Jun, Zhang, Xing-Xing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.10.2019
• Subjects: fatty liver; free fatty acids; gene expression; high fat diet; lipids; liver; luciferase; messenger RNA; mice; miR-146a-5p; NAFLD; NEAT1; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ROCK1; staining; transfection; Western blotting; miR-146a-5p; NAFLD; ROCK1; NEAT1

Nonalcoholic fatty liver disease (NAFLD) is a severe liver disease, which influences the health of people worldwide. However, the specific mechanism of the disease remains unknown, and effective treatments are still lacking. It was reported that Nuclear enriched abundant transcript 1 (NEAT1) obvious...