Role of Connective Tissue Growth Factor in the Pathogenesis of Conjunctival Scarring in Ocular Cicatricial Pemphigoid

• Published in: Investigative ophthalmology & visual science Vol. 44; no. 5; pp. 1998 - 2003
• Main Authors: Razzaque, Mohammed S, Foster, C. Stephen, Ahmed, A. Razzaque
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.05.2003; Association for Research in Vision and Ophtalmology
• Subjects: Biological and medical sciences; Bullous diseases of the skin; Cells, Cultured; Collagen Type I - biosynthesis; Conjunctiva - metabolism; Conjunctiva - pathology; Conjunctivitis - etiology; Conjunctivitis - metabolism; Connective Tissue Growth Factor; Dermatology; Diseases of eyelid, conjunctiva and lacrimal tracts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Humans; Immediate-Early Proteins - physiology; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins - physiology; Medical sciences; Ophthalmology; Pemphigoid, Benign Mucous Membrane - etiology; Pemphigoid, Benign Mucous Membrane - metabolism; Protein-Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta - immunology; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta - pharmacology; Transforming Growth Factor beta1; Bullous dermatosis; Human; Connective tissue; Skin disease; Scarring pemphigoid; Biopsy; Pathogenesis; Tissue factor; Conjunctiva; Growth factor

Conjunctival fibrosis due to excessive accumulation of collagens is an important histologic feature in ocular cicatricial pemphigoid (OCP). Studies have suggested a role of transforming growth factor (TGF)-beta1 in conjunctival fibrosis in patients with OCP. Connective tissue growth factor (CTGF) is...