Improved methods for biomarker analysis of the big five mycotoxins enables reliable exposure characterization in a population of childbearing age women in Rwanda

• Published in: Food and chemical toxicology Vol. 147; p. 111854
• Main Authors: Collins, Stephanie L., Walsh, Jacob P., Renaud, Justin B., McMillan, Amy, Rulisa, Stephen, Miller, J. David, Reid, Gregor, Sumarah, Mark W.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2021
• Subjects: Aflatoxin-lysine adduct; Biomarker; biomarkers; deoxynivalenol; diet; exposure characterization; food safety; High resolution LC-MS/MS; isotope dilution technique; Isotopically labelled standards; Multi-mycotoxin; ochratoxin A; Rwanda; stable isotopes; toxicology; urine; zearalenone; Rwanda; Isotopically labelled standards; Biomarker; Aflatoxin-lysine adduct; Multi-mycotoxin; High resolution LC-MS/MS
• ISSN: 0278-6915; 1873-6351; 1873-6351
• DOI: 10.1016/j.fct.2020.111854

Of the five agriculturally important mycotoxins, AFB1, FB1, DON, ZEA and OTA, a well-characterized biomarker of exposure in blood is only available for aflatoxin. Working with a population of 139 women of childbearing age in Rwanda, we undertook a comprehensive assessment of their dietary mycotoxin...