Longitudinal Characterization of Motor and Cognitive Deficits in a Model of Penetrating Ballistic-Like Brain Injury

• Published in: Journal of neurotrauma Vol. 27; no. 10; pp. 1911 - 1923
• Main Authors: Shear, Deborah A., Lu, Xi-Chun May, Bombard, Matthew C., Pedersen, Rebecca, Chen, Zhiyong, Davis, Angela, Tortella, Frank C.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.10.2010
• Subjects: Analysis of Variance; Animal cognition; Animals; Behavioral assessment; Brain; Brain damage; Brain Injuries - physiopathology; Cognition; Cognition - physiology; Frontal Lobe - injuries; Frontal Lobe - physiopathology; Head injuries; Injuries; Male; Maze Learning - physiology; Methods; Motor ability; Motor Activity - physiology; Physiological aspects; Rats; Rats, Sprague-Dawley; Rodents; Rotarod Performance Test; Spatial Behavior - physiology; United States

Traumatic brain injury (TBI) produces a wide range of motor and cognitive changes. While some neurological symptoms may respond to therapeutic intervention during the initial recovery period, others may persist for many years after the initial insult, and often have a devastating impact on quality o...