Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus

•SS homozygotes had significant greater stress induced cortisol response.•SS group had significant higher brain activation in dmPFC, dACC, and anterior insula.•The dmPFC was related to the appraisal of subjective stress. Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of t...

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Published inPhysiology & behavior Vol. 220; p. 112876
Main Authors Sun, Xiaoqiang, Li, Chuting, Zhong, Xue, Dong, Daifeng, Ming, Qingsen, Gao, Yidian, Xiong, Ge, Cheng, Chang, Zhao, Haofei, Wang, Xiang, Yao, Shuqiao
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2020
Subjects
5-HTTLPR
Alleles
Brain - diagnostic imaging
cortex
Cortisol
dmPFC
Functional magnetic resonance imaging
Genetic Loci
Genotype
homozygosity
Humans
loci
Magnetic Resonance Imaging
prefrontal cortex
psychological stress
serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Stress
Stress, Psychological - genetics
Functional magnetic resonance imaging
Cortisol
5-HTTLPR
Stress
dmPFC
Online AccessGet full text
ISSN0031-9384
1873-507X
1873-507X
DOI10.1016/j.physbeh.2020.112876

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Abstract •SS homozygotes had significant greater stress induced cortisol response.•SS group had significant higher brain activation in dmPFC, dACC, and anterior insula.•The dmPFC was related to the appraisal of subjective stress. Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
AbstractList Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
•SS homozygotes had significant greater stress induced cortisol response.•SS group had significant higher brain activation in dmPFC, dACC, and anterior insula.•The dmPFC was related to the appraisal of subjective stress. Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
ArticleNumber 112876
Author Li, Chuting
Wang, Xiang
Xiong, Ge
Gao, Yidian
Ming, Qingsen
Yao, Shuqiao
Zhong, Xue
Cheng, Chang
Zhao, Haofei
Sun, Xiaoqiang
Dong, Daifeng
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  surname: Zhao
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  givenname: Shuqiao
  surname: Yao
  fullname: Yao, Shuqiao
  email: shuqiaoyao@csu.edu.cn
  organization: Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China
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Keywords Functional magnetic resonance imaging
Cortisol
5-HTTLPR
Stress
dmPFC
Language English
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Snippet •SS homozygotes had significant greater stress induced cortisol response.•SS group had significant higher brain activation in dmPFC, dACC, and anterior...
Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of...
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SubjectTerms 5-HTTLPR
Alleles
Brain - diagnostic imaging
cortex
Cortisol
dmPFC
Functional magnetic resonance imaging
Genetic Loci
Genotype
homozygosity
Humans
loci
Magnetic Resonance Imaging
prefrontal cortex
psychological stress
serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Stress
Stress, Psychological - genetics
Title Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0031938420301931
https://dx.doi.org/10.1016/j.physbeh.2020.112876
https://www.ncbi.nlm.nih.gov/pubmed/32194071
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