Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

• Published in: Integrative biology (Cambridge) Vol. 9; no. 4; p. 290
• Main Authors: Maass, Christian, Stokes, Cynthia L, Griffith, Linda G, Cirit, Murat
• Format: Journal Article
• Language: English
• Published: England 18.04.2017
• Subjects: Animals; Cell Culture Techniques; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestines - drug effects; Intestines - metabolism; Kidney - drug effects; Kidney - metabolism; Liver - drug effects; Liver - metabolism; Models, Biological; Pharmacokinetics; Translational Medical Research

Microphysiological systems (MPS) provide relevant physiological environments in vitro for studies of pharmacokinetics, pharmacodynamics and biological mechanisms for translational research. Designing multi-MPS platforms is essential to study multi-organ systems. Typical design approaches, including...