The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans

• Published in: Current biology Vol. 33; no. 9; pp. 1625 - 1639.e4
• Main Authors: Levichev, Anastasia, Faumont, Serge, Berner, Rachel Z., Purcell, Zhifeng, White, Amanda M., Chicas-Cruz, Kathy, Lockery, Shawn R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 08.05.2023
• Subjects: AEA; Animals; appetite; Caenorhabditis elegans; Caenorhabditis elegans Proteins - genetics; calcium imaging; Cannabinoid Receptor Modulators - pharmacology; Cannabinoids; CB1; chemosensation; Endocannabinoids - pharmacology; energy homeostasis; Humans; Mammals; munchies; NPR-19; palatable food; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; NPR-19; CB1; chemosensation; cannabinoids; appetite; palatable food; AEA; calcium imaging; energy homeostasis; munchies

The ability of cannabis to increase food consumption has been known for centuries. In addition to producing hyperphagia, cannabinoids can amplify existing preferences for calorically dense, palatable food sources, a phenomenon called hedonic amplification of feeding. These effects result from the ac...