A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation

• Published in: Current biology Vol. 34; no. 11; pp. 2294 - 2307.e4
• Main Authors: Parnell, Emily J., Jenson, Erin E., Miller, Matthew P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.06.2024
• Subjects: bi-orientation; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Chromosome Segregation; Dam1 complex; kinetochore; Kinetochores - metabolism; Mps1; Ndc80 complex; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nuf2; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; SAC; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; spindle assembly checkpoint; Ndc80 complex; Dam1 complex; SAC; chromosome segregation; Mps1; Nuf2; spindle assembly checkpoint; kinetochore; bi-orientation

Accurate chromosome segregation relies on kinetochores carrying out multiple functions, including establishing and maintaining microtubule attachments, forming precise bi-oriented attachments between sister chromatids, and activating the spindle assembly checkpoint. Central to these processes is the...