Incorporation of Sulfated Hyaluronic Acid Macromers into Degradable Hydrogel Scaffolds for Sustained Molecule Delivery

• Published in: Biomaterials science Vol. 2; no. 5; pp. 693 - 702
• Main Authors: Purcell, Brendan P, Kim, Iris L, Chuo, Vanessa, Guinen, Theodore, Dorsey, Shauna M, Burdick, Jason A
• Format: Journal Article
• Language: English
• Published: England 01.01.2014
• Subjects: Affinity; Hyaluronic acid; Hydrogels; Hydroxyapatite; Nanostructure; Networks; Proteins; Scaffolds

Synthetically sulfated hyaluronic acid (HA) has been shown to bind proteins with high affinity through electrostatic interactions. While HA-based hydrogels have been used widely in recent years for drug delivery and tissue engineering applications, incorporation of sulfated HA into these networks to...