Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense

• Published in: Cellular and molecular life sciences : CMLS Vol. 81; no. 1; p. 203
• Main Authors: Zarin, Sheeba, Shariq, Mohd, Rastogi, Nilisha, Ahuja, Yashika, Manjunath, P., Alam, Anwar, Hasnain, Seyed Ehtesham, Ehtesham, Nasreen Zafar
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2024; Springer Nature B.V
• Subjects: Amino acids; Animals; antigens; Apoptosis; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biosynthesis; CD80 antigen; CD86 antigen; Cell Biology; Cell walls; Cytokines - metabolism; Enzymes; Helices; Histidine; Host-Pathogen Interactions - immunology; Humans; Immune response; Immune system; Immunity, Innate; immunologic receptors; Inflammation; interleukin-12; interleukin-6; Life Sciences; Macrophages; Macrophages - immunology; Macrophages - metabolism; Macrophages - microbiology; Major histocompatibility complex; Metabolism; Mice; Mycobacterium smegmatis - enzymology; Mycobacterium smegmatis - genetics; Mycobacterium smegmatis - metabolism; Mycobacterium smegmatis - pathogenicity; Mycobacterium tuberculosis; Mycobacterium tuberculosis - enzymology; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - pathogenicity; Nitrogen; Nitrogen metabolism; Novobiocin; Original Article; Pathogenesis; pathophysiology; Phenylalanine; phosphates; Proteins; pyridoxal; RAW 264.7 Cells; Reactive nitrogen species; secretion; Survival; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Transaminases; Transaminases - genetics; Transaminases - metabolism; Tryptophan; Tuberculosis; Tuberculosis - immunology; Tuberculosis - microbiology; Tyrosine; Virulence; Histidine biosynthesis; M2 macrophage polarization; Pyroptosis; Necroptosis; TLR4; Apoptosis

Nitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M. tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and uptake of various amino acids from host cells for metabolic demands. Pyridoxal phosphate-dependent histidinol phosp...