Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense - Zarin, Sheeba; Shariq, Mohd; Rastogi, Nilisha; Ahuja, Yashika; Manjunath, P.; Alam, Anwar; Hasnain, Seyed Ehtesham; Ehtesham, Nasreen Zafar (Cellular and molecular life sciences : CMLS, 2024)
Keywords: Amino acids; Animals; antigens; Apoptosis; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biosynthesis; CD80 antigen; CD86 antigen; Cell Biology; Cell walls; Cytokines - metabolism; Enzymes; Helices; Histidine; Host-Pathogen Interactions - immunology; Humans; Immune response; Immune system; Immunity, Innate; immunologic receptors; Inflammation; interleukin-12; interleukin-6; Life Sciences; Macrophages; Macrophages - immunology; Macrophages - metabolism; Macrophages - microbiology; Major histocompatibility complex; Metabolism; Mice; Mycobacterium smegmatis - enzymology; Mycobacterium smegmatis - genetics; Mycobacterium smegmatis - metabolism; Mycobacterium smegmatis - pathogenicity; Mycobacterium tuberculosis; Mycobacterium tuberculosis - enzymology; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - pathogenicity; Nitrogen; Nitrogen metabolism; Novobiocin; Original Article; Pathogenesis; pathophysiology; Phenylalanine; phosphates; Proteins; pyridoxal; RAW 264.7 Cells; Reactive nitrogen species; secretion; Survival; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Transaminases; Transaminases - genetics; Transaminases - metabolism; Tryptophan; Tuberculosis; Tuberculosis - immunology; Tuberculosis - microbiology; Tyrosine; Virulence; Histidine biosynthesis; M2 macrophage polarization; Pyroptosis; Necroptosis; TLR4; Apoptosis