Developmental Alterations of Colonic microRNA Profiles Imply Potential Biological Functions in Kid Goats

The colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age. However, whether the microRNA expression in the colon of goats is affected by age is still unclear. In the current study, we analyzed the tran...

Full description

Saved in:
Bibliographic Details
Published inAnimals (Basel) Vol. 12; no. 12; p. 1533
Main Authors Yan, Qiongxian, Tian, Lina, Chen, Wenxun, Kang, Jinhe, Tang, Shaoxun, Tan, Zhiliang
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 14.06.2022
MDPI
Subjects
Adhesion
Age
Binding sites
Carbohydrates
Cell adhesion
Cell adhesion molecules
Cell walls
Cellulose
Colon
colon development
dynamic microRNA
Enrichment
Enzymes
ErbB protein
Fermentation
Gene expression
Genes
Genomics
goat
Goats
Hemicellulose
highly expressed microRNA
Homeostasis
Large intestine
Maintenance
MAP kinase
Microorganisms
MicroRNAs
miRNA
Mucosal immunity
Permeability
Prevention
Signal transduction
Software
Surveillance
Transcriptomes
Wnt protein
Beijing China
United States > US
China
Online AccessGet full text

Cover

Abstract The colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age. However, whether the microRNA expression in the colon of goats is affected by age is still unclear. In the current study, we analyzed the transcriptomes of colon microRNAs during preweaning (Day 10 and Day 25) and postweaning (Day 31). A total of 1572 microRNAs were identified in the colon tissues. Of these, 39 differentially expressed microRNAs (DEmiRNAs) and 88 highly expressed microRNAs (HEmiRNAs) were screened. The target genes regulated by the DEmiRNAs and HEmiRNAs were commonly enriched in the MAPK signaling pathway, Wnt signaling pathway, Hippo signaling pathway, cell adhesion molecules, focal adhesion, and adherens junction. Remarkably, the targeted genes of the DEmiRNAs were highly enriched for the prevention of microbial invasion via the Erbb−MAPK network while the targeted genes of HEmiRNAs contributed to the permeable barrier maintenance and cell damage surveillance. Additionally, there were eight different expression profiles of 87 dynamic miRNAs, in which approximately half of them were affected by age. Taken together, our study reveals the different roles of DEmiRNAs, HEmiRNAs, and dynamic microRNAs in the development of the colon and gives new insights into the regulatory mechanism of colon development in goats.
AbstractList Simple SummaryThe colon plays a crucial role in the fermentation and utilization of cell wall carbohydrates, cellulose, and hemicellulose in ruminants. MicroRNAs have been reported to be involved in regulating the gastrointestinal development and maintaining intestinal homeostasis of mammals. In this study, we first reveal the microRNA expression profiles in the colon of kid goats. Meanwhile, we found that targeted genes of DEmiRNAs were highly enriched for the prevention of microbial invasion via the Erbb−MAPK network while targeted genes of HEmiRNAs contributed to the permeable barrier maintenance and surveillance of cell damage. Additionally, more than half of the microRNAs showed a developmentally dynamic expression in the colon of kid goats. This study disclosed microRNA-based biological functions in the regulation of colon development in ruminants.AbstractThe colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age. However, whether the microRNA expression in the colon of goats is affected by age is still unclear. In the current study, we analyzed the transcriptomes of colon microRNAs during preweaning (Day 10 and Day 25) and postweaning (Day 31). A total of 1572 microRNAs were identified in the colon tissues. Of these, 39 differentially expressed microRNAs (DEmiRNAs) and 88 highly expressed microRNAs (HEmiRNAs) were screened. The target genes regulated by the DEmiRNAs and HEmiRNAs were commonly enriched in the MAPK signaling pathway, Wnt signaling pathway, Hippo signaling pathway, cell adhesion molecules, focal adhesion, and adherens junction. Remarkably, the targeted genes of the DEmiRNAs were highly enriched for the prevention of microbial invasion via the Erbb−MAPK network while the targeted genes of HEmiRNAs contributed to the permeable barrier maintenance and cell damage surveillance. Additionally, there were eight different expression profiles of 87 dynamic miRNAs, in which approximately half of them were affected by age. Taken together, our study reveals the different roles of DEmiRNAs, HEmiRNAs, and dynamic microRNAs in the development of the colon and gives new insights into the regulatory mechanism of colon development in goats.
The colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age. However, whether the microRNA expression in the colon of goats is affected by age is still unclear. In the current study, we analyzed the transcriptomes of colon microRNAs during preweaning (Day 10 and Day 25) and postweaning (Day 31). A total of 1572 microRNAs were identified in the colon tissues. Of these, 39 differentially expressed microRNAs (DEmiRNAs) and 88 highly expressed microRNAs (HEmiRNAs) were screened. The target genes regulated by the DEmiRNAs and HEmiRNAs were commonly enriched in the MAPK signaling pathway, Wnt signaling pathway, Hippo signaling pathway, cell adhesion molecules, focal adhesion, and adherens junction. Remarkably, the targeted genes of the DEmiRNAs were highly enriched for the prevention of microbial invasion via the Erbb−MAPK network while the targeted genes of HEmiRNAs contributed to the permeable barrier maintenance and cell damage surveillance. Additionally, there were eight different expression profiles of 87 dynamic miRNAs, in which approximately half of them were affected by age. Taken together, our study reveals the different roles of DEmiRNAs, HEmiRNAs, and dynamic microRNAs in the development of the colon and gives new insights into the regulatory mechanism of colon development in goats.
Author Tian, Lina
Tang, Shaoxun
Yan, Qiongxian
Tan, Zhiliang
Chen, Wenxun
Kang, Jinhe
AuthorAffiliation 2 Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China
1 CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China; yanqx14@isa.ac.cn (Q.Y.); tianlina18@mails.ucas.ac.cn (L.T.); chenwenxun@189.cn (W.C.); kangjh@isa.ac.cn (J.K.); zltan@isa.ac.cn (Z.T.)
AuthorAffiliation_xml – name: 1 CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China; yanqx14@isa.ac.cn (Q.Y.); tianlina18@mails.ucas.ac.cn (L.T.); chenwenxun@189.cn (W.C.); kangjh@isa.ac.cn (J.K.); zltan@isa.ac.cn (Z.T.)
– name: 2 Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China
Author_xml – sequence: 1
  givenname: Qiongxian
  orcidid: 0000-0003-0035-6819
  surname: Yan
  fullname: Yan, Qiongxian
– sequence: 2
  givenname: Lina
  surname: Tian
  fullname: Tian, Lina
– sequence: 3
  givenname: Wenxun
  surname: Chen
  fullname: Chen, Wenxun
– sequence: 4
  givenname: Jinhe
  orcidid: 0000-0002-9805-1695
  surname: Kang
  fullname: Kang, Jinhe
– sequence: 5
  givenname: Shaoxun
  surname: Tang
  fullname: Tang, Shaoxun
– sequence: 6
  givenname: Zhiliang
  surname: Tan
  fullname: Tan, Zhiliang
BookMark eNpdkl1PFDEUhhsDEUSu_AOTeGNiVvo5nd6YrKvgBqLE6HXTac8s3XTapZ0h4d9bXGKA9qIn7Xue89HzBh3EFAGhdwR_YkzhMxM9oXULxl6hY4plu6AtEQdP7CN0WsoW1yUFI4K8RkdMSKY6iY_RzVe4g5B2I8TJhGYZJshm8imWJg3NKoUUvW1Gb3P69WPZXOc0-AClWY-7cN9cp6n6-er4xVfpxttqns_R7gk-NpfeNRfJTOUtOhxMKHD6eJ6gP-fffq--L65-XqxXy6uF5YJOi952oreDG7iThtC-JUwop6DWaFXLBQPJZecUbruBYRBkYMLV4jE3PWZCsBO03nNdMlu9y340-V4n4_W_i5Q32uTJ2wDaiA64tMAHgblyUONwYSg2vXBcUVZZn_es3dyP4GytNZvwDPr8JfobvUl3WlGieMcr4MMjIKfbGcqkR18shGAipLlo2nYEs45TUqXvX0i3ac6xtqqqpKp9YPgho497Vf2PUjIM_5MhWD8MhH4yEOwvNCaoZg
CitedBy_id crossref_primary_10_3390_vetsci10010057
Cites_doi 10.1186/gb-2003-5-1-r1
10.1371/journal.pone.0011541
10.7150/ijbs.7.180
10.1038/nri3608
10.1016/j.molcel.2014.02.013
10.1186/gb-2010-11-10-r106
10.1016/j.anifeedsci.2011.12.004
10.1093/nar/gky1141
10.1007/s11894-010-0131-2
10.1006/meth.2001.1262
10.1158/1535-7163.MCT-11-0592
10.1242/jeb.055582
10.1016/j.clnu.2005.11.004
10.1371/journal.pone.0092592
10.1152/physiolgenomics.00081.2006
10.1101/gr.082701.108
10.1152/ajpregu.00425.2004
10.1093/cdn/nzz122
10.7554/eLife.05005
10.1016/j.molimm.2018.12.027
10.1093/bioinformatics/bti1022
10.1016/j.ygeno.2018.05.009
10.1038/sdata.2019.13
10.3389/fmicb.2019.02125
10.1128/JVI.01900-10
10.32614/RJ-2013-005
10.1111/j.1349-7006.2011.02007.x
10.1016/j.yexmp.2014.04.009
10.1152/ajpgi.00020.2017
10.1101/gad.212522.112
10.3390/biology10090832
10.1016/j.meegid.2019.103945
10.1186/1471-2105-7-191
10.1016/j.jaci.2017.07.019
10.1371/journal.ppat.1006152
10.3390/ani10111951
10.3389/fvets.2020.00507
10.1371/journal.pone.0193371
10.3390/ijms17040499
10.2527/jas.2015-0081
10.3390/ani10081417
ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022 by the authors. 2022
DBID AAYXX
CITATION
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/ani12121533
DatabaseName CrossRef
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central
ProQuest One Academic UKI Edition
ProQuest Central Essentials
ProQuest Central Korea
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Academic
ProQuest Central China
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Zoology
EISSN 2076-2615
ExternalDocumentID oai_doaj_org_article_a58e47ce4f5049de9d945a20ab5d4923
10_3390_ani12121533
GeographicLocations Beijing China
United States--US
China
GeographicLocations_xml – name: China
– name: Beijing China
– name: United States--US
GrantInformation_xml – fundername: open project of the Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process
  grantid: ISA2020213
– fundername: National Natural Science Foundation of China
  grantid: 31730092
GroupedDBID 5VS
7XC
8FE
8FH
AAFWJ
AAHBH
AAYXX
ABDBF
AFKRA
AFPKN
ALMA_UNASSIGNED_HOLDINGS
APEBS
ATCPS
BBNVY
BENPR
BHPHI
CCPQU
CITATION
DIK
EAD
EAP
EPL
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
ISR
ITC
LK8
M0K
M48
M7P
MODMG
M~E
OK1
OZF
PATMY
PGMZT
PIMPY
PROAC
PYCSY
RPM
TUS
ZBA
ABUWG
AZQEC
DWQXO
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c452t-bc85bcfdf4d7a12b61359d9e212c96453e7478d9068f30e51f35d53304ab03553
IEDL.DBID RPM
ISSN 2076-2615
IngestDate Tue Oct 22 14:54:20 EDT 2024
Tue Sep 17 21:18:41 EDT 2024
Fri Aug 16 03:37:17 EDT 2024
Wed Oct 30 03:04:31 EDT 2024
Fri Aug 23 04:30:07 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c452t-bc85bcfdf4d7a12b61359d9e212c96453e7478d9068f30e51f35d53304ab03553
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-9805-1695
0000-0003-0035-6819
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219484/
PMID 35739870
PQID 2679613303
PQPubID 2032438
ParticipantIDs doaj_primary_oai_doaj_org_article_a58e47ce4f5049de9d945a20ab5d4923
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9219484
proquest_miscellaneous_2681038421
proquest_journals_2679613303
crossref_primary_10_3390_ani12121533
PublicationCentury 2000
PublicationDate 20220614
PublicationDateYYYYMMDD 2022-06-14
PublicationDate_xml – month: 6
  year: 2022
  text: 20220614
  day: 14
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle Animals (Basel)
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Zhu (ref_46) 2017; 312
Agarwal (ref_31) 2015; 4
Jiao (ref_6) 2016; 94
Eugster (ref_37) 2013; 5
Azzalini (ref_35) 1990; 39
Seo (ref_41) 2018; 141
Sun (ref_18) 2019; 6
ref_30
Izumiya (ref_43) 2011; 102
Ernst (ref_28) 2005; 21
Guilloteau (ref_9) 2009; 60
ref_17
ref_15
Livak (ref_38) 2001; 25
Zhou (ref_13) 2019; 317
Plaizier (ref_3) 2012; 172
Friedman (ref_32) 2009; 19
Zhang (ref_20) 2019; 75
Ueno (ref_44) 2011; 11
Carr (ref_36) 1987; 82
Faridi (ref_45) 2020; 7
Wu (ref_12) 2019; 3
Wei (ref_24) 2011; 7
Nam (ref_33) 2014; 53
ref_22
ref_21
Do (ref_16) 2019; 111
ref_42
Debras (ref_11) 2006; 25
Kim (ref_7) 2010; 12
Kozomara (ref_25) 2019; 47
Kostic (ref_5) 2013; 27
ref_29
Enright (ref_34) 2003; 5
Stumpff (ref_2) 2011; 214
Coutinho (ref_19) 2007; 29
ref_27
ref_26
Graham (ref_1) 2005; 288
Liu (ref_14) 2017; 8
Meyer (ref_23) 2011; 85
Peterson (ref_8) 2014; 14
Li (ref_10) 2019; 10
ref_4
Huang (ref_39) 2019; 107
Fourie (ref_40) 2014; 96
References_xml – volume: 5
  start-page: R1
  year: 2003
  ident: ref_34
  article-title: MicroRNA targets in Drosophila
  publication-title: Genome Biol.
  doi: 10.1186/gb-2003-5-1-r1
  contributor:
    fullname: Enright
– volume: 82
  start-page: 424
  year: 1987
  ident: ref_36
  article-title: Scatterplot matrix techniques for large-N
  publication-title: J. Am. Stat. Assoc.
  contributor:
    fullname: Carr
– ident: ref_22
  doi: 10.1371/journal.pone.0011541
– volume: 7
  start-page: 180
  year: 2011
  ident: ref_24
  article-title: Novel and Conserved Micrornas in Dalian Purple Urchin (Strongylocentrotus Nudus) Identified by Next Generation Sequencing
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.7.180
  contributor:
    fullname: Wei
– volume: 14
  start-page: 141
  year: 2014
  ident: ref_8
  article-title: Intestinal epithelial cells: Regulators of barrier function and immune homeostasis
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3608
  contributor:
    fullname: Peterson
– volume: 53
  start-page: 1031
  year: 2014
  ident: ref_33
  article-title: Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.02.013
  contributor:
    fullname: Nam
– ident: ref_30
  doi: 10.1186/gb-2010-11-10-r106
– volume: 172
  start-page: 9
  year: 2012
  ident: ref_3
  article-title: Subacute ruminal acidosis (SARA), endotoxins and health consequences
  publication-title: Anim. Feed Sci. Technol.
  doi: 10.1016/j.anifeedsci.2011.12.004
  contributor:
    fullname: Plaizier
– volume: 47
  start-page: D155
  year: 2019
  ident: ref_25
  article-title: miRBase: From microRNA sequences to function
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1141
  contributor:
    fullname: Kozomara
– volume: 12
  start-page: 319
  year: 2010
  ident: ref_7
  article-title: Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
  publication-title: Curr. Gastroenterol. Rep.
  doi: 10.1007/s11894-010-0131-2
  contributor:
    fullname: Kim
– volume: 25
  start-page: 402
  year: 2001
  ident: ref_38
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT Method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
  contributor:
    fullname: Livak
– volume: 11
  start-page: 244
  year: 2011
  ident: ref_44
  article-title: Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-11-0592
  contributor:
    fullname: Ueno
– volume: 214
  start-page: 2871
  year: 2011
  ident: ref_2
  article-title: Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins
  publication-title: J. Exp. Biol.
  doi: 10.1242/jeb.055582
  contributor:
    fullname: Stumpff
– volume: 25
  start-page: 477
  year: 2006
  ident: ref_11
  article-title: Oligosaccharides isolated from goat milk reduce intestinal inflammation in a rat model of dextran sodium sulfate-induced colitis
  publication-title: Clin. Nutr.
  doi: 10.1016/j.clnu.2005.11.004
  contributor:
    fullname: Debras
– ident: ref_15
  doi: 10.1371/journal.pone.0092592
– volume: 39
  start-page: 357
  year: 1990
  ident: ref_35
  article-title: A look at some data on the old faithful geyser
  publication-title: J. R. Stat. Soc. Ser. C Appl. Stat.
  contributor:
    fullname: Azzalini
– volume: 29
  start-page: 35
  year: 2007
  ident: ref_19
  article-title: Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00081.2006
  contributor:
    fullname: Coutinho
– volume: 19
  start-page: 92
  year: 2009
  ident: ref_32
  article-title: Most mammalian mRNAs are conserved targets of microRNAs
  publication-title: Genome Res.
  doi: 10.1101/gr.082701.108
  contributor:
    fullname: Friedman
– volume: 288
  start-page: R173
  year: 2005
  ident: ref_1
  article-title: Functional organization of the bovine rumen epithelium
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00425.2004
  contributor:
    fullname: Graham
– volume: 3
  start-page: nzz122
  year: 2019
  ident: ref_12
  article-title: Dietary Depletion of Milk Exosomes and Their MicroRNA Cargos Elicits a Depletion of miR-200a-3p and Elevated Intestinal Inflammation and Chemokine (C-X-C Motif) Ligand 9 Expression in Mdr1a-/- Mice
  publication-title: Curr. Dev. Nutr.
  doi: 10.1093/cdn/nzz122
  contributor:
    fullname: Wu
– volume: 317
  start-page: G618
  year: 2019
  ident: ref_13
  article-title: Dietary bovine milk exosomes elicit changes in bacterial communities in C57BL/6 mice
  publication-title: Am. J. Physiol. Liver Physiol.
  contributor:
    fullname: Zhou
– volume: 4
  start-page: e05005
  year: 2015
  ident: ref_31
  article-title: Predicting effective microRNA target sites in mammalian mRNAs
  publication-title: eLife
  doi: 10.7554/eLife.05005
  contributor:
    fullname: Agarwal
– volume: 107
  start-page: 1
  year: 2019
  ident: ref_39
  article-title: IL-16 regulates macrophage polarization as a target gene of mir-145-3p
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2018.12.027
  contributor:
    fullname: Huang
– volume: 21
  start-page: i159
  year: 2005
  ident: ref_28
  article-title: Clustering short time series gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti1022
  contributor:
    fullname: Ernst
– volume: 111
  start-page: 849
  year: 2019
  ident: ref_16
  article-title: Integration of miRNA weighted gene co-expression network and miRNA-mRNA co-expression analyses reveals potential regulatory functions of miRNAs in calf rumen development
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2018.05.009
  contributor:
    fullname: Do
– volume: 6
  start-page: 190013
  year: 2019
  ident: ref_18
  article-title: MicroRNA expression profiles across blood and different tissues in cattle
  publication-title: Sci. Data
  doi: 10.1038/sdata.2019.13
  contributor:
    fullname: Sun
– volume: 10
  start-page: 2125
  year: 2019
  ident: ref_10
  article-title: Characterization and Comparison of Microbiota in the Gastrointestinal Tracts of the Goat (Capra hircus) During Preweaning Development
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.02125
  contributor:
    fullname: Li
– volume: 85
  start-page: 378
  year: 2011
  ident: ref_23
  article-title: Cytomegalovirus MicroRNA Expression Is Tissue Specific and Is Associated with Persistence
  publication-title: J. Virol.
  doi: 10.1128/JVI.01900-10
  contributor:
    fullname: Meyer
– volume: 5
  start-page: 53
  year: 2013
  ident: ref_37
  article-title: osmar: OpenStreetMap and R
  publication-title: R J.
  doi: 10.32614/RJ-2013-005
  contributor:
    fullname: Eugster
– volume: 102
  start-page: 1615
  year: 2011
  ident: ref_43
  article-title: Systematic exploration of cancer-associated microRNA through functional screening assays
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2011.02007.x
  contributor:
    fullname: Izumiya
– volume: 60
  start-page: 37
  year: 2009
  ident: ref_9
  article-title: Gastrointestinal tract and digestion in the young ruminant: Ontogenesis, adaptations, consequences and manipulations
  publication-title: J. Physiol. Pharmacol.
  contributor:
    fullname: Guilloteau
– volume: 96
  start-page: 422
  year: 2014
  ident: ref_40
  article-title: Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2014.04.009
  contributor:
    fullname: Fourie
– volume: 312
  start-page: G434
  year: 2017
  ident: ref_46
  article-title: MicroRNA-29a mediates the impairment of intestinal epithelial integrity induced by intrauterine growth restriction in pig
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00020.2017
  contributor:
    fullname: Zhu
– volume: 27
  start-page: 701
  year: 2013
  ident: ref_5
  article-title: Exploring host-microbiota interactions in animal models and humans
  publication-title: Genes Dev.
  doi: 10.1101/gad.212522.112
  contributor:
    fullname: Kostic
– ident: ref_26
  doi: 10.3390/biology10090832
– volume: 75
  start-page: 103945
  year: 2019
  ident: ref_20
  article-title: Analysis of the microRNA expression profiles in feline kidney cell line infected with feline panleukopenia virus
  publication-title: Infect. Genet. Evol.
  doi: 10.1016/j.meegid.2019.103945
  contributor:
    fullname: Zhang
– ident: ref_29
  doi: 10.1186/1471-2105-7-191
– volume: 141
  start-page: 1382
  year: 2018
  ident: ref_41
  article-title: MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-beta receptor II regulation
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2017.07.019
  contributor:
    fullname: Seo
– ident: ref_42
  doi: 10.1371/journal.ppat.1006152
– ident: ref_17
  doi: 10.3390/ani10111951
– volume: 7
  start-page: 507
  year: 2020
  ident: ref_45
  article-title: Intestinal Expression of miR-130b, miR-410b, and miR-98a in Experimental Canine Echinococcosis by Stem-Loop RT-qPCR
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2020.00507
  contributor:
    fullname: Faridi
– ident: ref_4
  doi: 10.1371/journal.pone.0193371
– ident: ref_27
  doi: 10.3390/ijms17040499
– volume: 94
  start-page: 2506
  year: 2016
  ident: ref_6
  article-title: Age and feeding system (supplemental feeding versus grazing) modulates colonic bacterial succession and host mucosal immune maturation in goats
  publication-title: J. Anim. Sci.
  doi: 10.2527/jas.2015-0081
  contributor:
    fullname: Jiao
– volume: 8
  start-page: 429
  year: 2017
  ident: ref_14
  article-title: Starter Feeding Supplementation Alters Colonic Mucosal Bacterial Communities and Modulates Mucosal Immune Homeostasis in Newborn Lambs
  publication-title: Front. Microbiol.
  contributor:
    fullname: Liu
– ident: ref_21
  doi: 10.3390/ani10081417
SSID ssj0000753151
Score 2.2764301
Snippet The colon is a crucial digestive organ of the hind gut in ruminants. The bacterial diversity and mucosal immune maturation in this region are related to age....
Simple SummaryThe colon plays a crucial role in the fermentation and utilization of cell wall carbohydrates, cellulose, and hemicellulose in ruminants....
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 1533
SubjectTerms Adhesion
Age
Binding sites
Carbohydrates
Cell adhesion
Cell adhesion molecules
Cell walls
Cellulose
Colon
colon development
dynamic microRNA
Enrichment
Enzymes
ErbB protein
Fermentation
Gene expression
Genes
Genomics
goat
Goats
Hemicellulose
highly expressed microRNA
Homeostasis
Large intestine
Maintenance
MAP kinase
Microorganisms
MicroRNAs
miRNA
Mucosal immunity
Permeability
Prevention
Signal transduction
Software
Surveillance
Transcriptomes
Wnt protein
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS-UwEA8iCF7E9QOfvpUIXotpPvqSoyv7FEURURAvJWkSrOy2y7568L93pnlKe_LipYdmWpKZJDOTmfyGkOO8CIK7GDNunMykViZz4IVlks-YlRw0dMCI7vVNcfEgLx_V46DUF-aEJXjgxLgTq3SQsyrIqMCY9cF4I5XlzDrlEVys332ZGThTLyk8J0CXpQt5Avz6E9vUOUcoBSFGKqhH6h-Zl-PkyIG2mW-SjaWZSE9T936QldBskbWntj8E3ybPg1wfJPvTYyPjDKJtpGdA1dQV_YvJdnc3p_Q2FeZeUMQCfqO3bYc5QvBhqkSJcqJzUHDpD3VDr2pPz1vbLXbIw_z3_dlFtqyZkFVS8S5zlVauij5KP7M5d6CtFbAswNArU0glAgLme8MKHQULKo9CecwwldYxsD3ELllt2ibsEYoBT6mNjoUBn8lafPpYRK-rPDBmJ-T4g43lvwSNUYJLgdwuB9yekF_I4k8SxLPuX4CUy6WUy6-kPCHTDwGVy0W2KDmegYGPzaD56LMZlgfGPGwT2lek0QgBD7NuQmYjwY46NG5p6uceaNvAdi613P-OERyQdY43J7DskZyS1e7_a_gJ9kznDvup-w6LH_SO
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVkhcEOUhUgoyUq9RHT-y8Qm1VZeqiNWqolLFJbJjm0aCpO2mB_49M0l22Vy45BBPbGfG9njG428AjrI8SOFiTIVxKlWFNqlDKyxVYs6tEqihA53oflvmF9fq8kbfjA639RhWuVkT-4XatxX5yI8FOTzQoOLy8919Slmj6HR1TKHxFPawWs5nsHd6vlxdbb0sqBAl6rThYp5E-_7YNnUmCFJByokq6hH7J9vMaZDkjtZZvIQX43aRnQzy3YcnoXkFz360vTP8NdzuxPwQ2a8eI5lGEmsjO0Oqpq7Ybwq6u1qesNWQoHvNCBP4D1u1HcUK4YdDRkqSF1ugohtqqBv2tfbsS2u79Ru4Xpx_P7tIx9wJaaW06FJXFdpV0Ufl5zYTDlmnjTcBf70yudIyEHC-NzwvouRBZ1FqT5GmyjqOexD5FmZN24R3wOjgUxWmiLlB28laevqYR19UWeDcJnC0YWN5N0BklGhaELfLHW4ncEos3pIQrnX_on34WY7TpLS6CGpeBRWxTeMDdllpK7h12hOUXAKHGwGV42Rbl_-GRgKftsU4TejswzahfSSagqDgcfQlMJ8IdtKhaUlT3_aA2waXdVWog_83_h6eC7obQYmN1CHMuofH8AF3LJ37OA7Lv8JH7Tg
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Nb9QwEB2VIiQuFZ9ioSAj9RpInHHWPiBUKpYKRFUhVqq4RHZs06CSlN1Uov-emSRbbRAHLjnETmKP7cw8z_gNwEFWhFy6GBNpHCaolUkcobAE5Ty1KElDB_bofj4pjpf48Uyd7cAmGecowPU_oR3nk1quLl79_nX9lhb8G0acBNlf26bOJLMk5PktuC2RIDrH8I12_o_BW5dnfSpGSbg9IdSghrN6fz8_0U49if_E8pzGTW4posU92BstSHE4DPl92AnNA7jzre33xx_C-VYYEFe76GmTeXKJNoojqtXUlfjJcXhfTg7F6ZCzey2YJvhanLYdhw_Rg0OSSh5CsSDdN7yhbsSn2osPre3Wj2C5eP_16DgZ0ykkFSrZJa7SylXRR_Rzm0lHilwZbwJ1vTIFqjwwl743aaFjngaVxVx5Dj5F61IyS_LHsNu0TXgCgn2hqI2OhSE4ZS1ffSyi11UW0tTO4GAjxvJyYM0oCW2wtMstac_gHYv4pgpTXfc32tX3clw5pVU64LwKGOmbxgdqMiorU-uUZ3a5GexvBqjcTJ9S8vYYwe-Uil_eFNPKYXeIbUJ7xXU0s8PThJzBfDKwkwZNS5r6vOfgNvSnR41P_6-jz-Cu5GMTnPMI92G3W12F52TMdO5FP1H_AG678g8
  priority: 102
  providerName: Scholars Portal
Title Developmental Alterations of Colonic microRNA Profiles Imply Potential Biological Functions in Kid Goats
URI https://www.proquest.com/docview/2679613303
https://search.proquest.com/docview/2681038421
https://pubmed.ncbi.nlm.nih.gov/PMC9219484
https://doaj.org/article/a58e47ce4f5049de9d945a20ab5d4923
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDBbaDgN2GfbEsnWBBvTqxtbDlo5t0KzYkCAoVqDYxZAsaXXRyEXjHvbvR9pOEV938cGibIGkQFKkPhJykuWeMxtCwrQViVBSJxaisESwIjWCgYX2mNFdrvLLa_HjRt4cELm7C9MV7Ve2Po33m9NY33a1lQ-bararE5utl3MN20woMTskh6CgeyH6XZ-Z42DG-rt4HEL6mYl1xhBFgWPXHC4LDoF2OjJEHV7_yMkcl0ju2ZzFG_J6cBbpWb-ot-TAx3fk5e-mOwp_T273Kn6Q7L5DSEY9ok2gc6CKdUU3WHJ3tTqj674995YiIvBfum5arBSCiX0_SpQWXYCZ679QR_qzdvR7Y9rtB3K9uPg1v0yGzglJJSRrE1spaavggnCFyZgFmy210x64UOlcSO4RNt_pNFeBp15mgUuHdabC2BQ8EP6RHMUm-k-EYtpTKK1CriFyMgafLuTBqSrzaWom5GTHxvKhB8goIbBAxpd7jJ-Qc2TxMwmiWncvmsc_5SDb0kjlRVF5EeCf2nlYspCGpcZKh0ByE3K8E1A5bLVtyfAkDCLtFIa_PQ_DJsHMh4m-eUIahUDwoHsTUowEO1rQeAS0r4PbHrTt83_P_EJeMbw0gR2PxDE5ah-f_FdwZVo7JS_OL1brq2l3FADPpVDTTp3_ARut-FI
link.rule.ids 230,315,730,783,787,867,888,2109,2228,21400,24330,27936,27937,33756,33757,43817,53804,53806,74636
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB61oKq9VH2qaWnrSlwjEj-y9qkCxLItsFohkFAvkRPbJRIklA2H_vvOJNllc-klh9hJnJmx5-HxNwC7aeYFL0KIuSlkLLUycYFeWCz5JLGSo4b2tKN7Ns9ml_LnlboaAm7LIa1ytSZ2C7VrSoqR73EKeKBDlYjvd39iqhpFu6tDCY2nsE1QVeh8bR8czRfn6ygLKkSBOq0_mCfQv9-zdZVyglQQYqSKOsT-kZk5TpLc0DrTV_ByMBfZfs_f1_DE12_g2a-mC4a_heuNnB_qdtNhJJMksSawQ-xVVyW7paS78_k-W_QFupeMMIH_skXTUq4QPthXpCR-sSkquv4NVc1OKseOG9su38Hl9OjicBYPtRPiUirexkWpVVEGF6Sb2JQXSDplnPH466XJpBKegPOdSTIdROJVGoRylGkqbZGgDSLew1bd1P4DMNr4lNrokBn0naylqwtZcLpMfZLYCHZXZMzveoiMHF0Lona-Qe0IDojE6y6Ea93daO5_58M0ya3SXk5KLwN-0ziPQ5bK8sQWyhGUXAQ7Kwblw2Rb5o-iEcG3dTNOE9r7sLVvHqiPJih4lL4IJiPGjgY0bqmr6w5w2-CyLrX8-P-Pf4Xns4uz0_z0x_zkE7zgdE6CihzJHdhq7x_8Z7Re2uLLIKL_ACuw8DI
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BViAuiKcIFDBSr9EmfiTxCbWlS6GwWlVUqrhETmzTSJCUbnrg3zOTeJfNhUsOsZM4M2PPw-NvAA7SzAleeR9zXclYFkrHFXphseR5YiRHDe1oR_frMju9kJ8v1WXIf1qHtMrNmjgs1LarKUY-5xTwQIcqEXMf0iJWHxbvr3_HVEGKdlpDOY27sJcTCtYM9o5OlqvzbcQFlaNA_TYe0hPo689N26Sc4BWEmKilAb1_YnJOEyZ3NNDiETwMpiM7HHn9GO649gnc-94NgfGncLWT_0Pdfg54ySRVrPPsGHu1Tc1-UQLe-fKQrcZi3WtG-MB_2KrrKW8IHxyrUxLv2AKV3viGpmVnjWUfO9Ovn8HF4uTb8Wkc6ijEtVS8j6u6UFXtrZc2NymvkIxKW-3w12udSSUcgehbnWSFF4lTqRfKUtapNFWC9oh4DrO2a90LYLQJKgtd-EyjH2UMXa3PvC3q1CWJieBgQ8byeoTLKNHNIGqXO9SO4IhIvO1CGNfDje7mRxmmTGlU4WReO-nxm9o6HLJUhiemUpZg5SLY3zCoDBNvXf4TkwjebZtxytA-iGldd0t9CoKFR0mMIJ8wdjKgaUvbXA3g2xqXeFnIl___-Fu4j9JZfvm0PHsFDzgdmaB6R3IfZv3NrXuNhkxfvQkS-hc5N_Rm
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Developmental+Alterations+of+Colonic+microRNA+Profiles+Imply+Potential+Biological+Functions+in+Kid+Goats&rft.jtitle=Animals+%28Basel%29&rft.au=Yan%2C+Qiongxian&rft.au=Tian%2C+Lina&rft.au=Chen%2C+Wenxun&rft.au=Kang%2C+Jinhe&rft.date=2022-06-14&rft.issn=2076-2615&rft.eissn=2076-2615&rft.volume=12&rft.issue=12&rft.spage=1533&rft_id=info:doi/10.3390%2Fani12121533&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_ani12121533
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-2615&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-2615&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-2615&client=summon