SARS-CoV-2 Evolution and Patient Immunological History Shape the Breadth and Potency of Antibody-Mediated Immunity

• Published in: The Journal of infectious diseases Vol. 227; no. 1; pp. 40 - 49
• Main Authors: Manali, Maria, Bissett, Laura A, Amat, Julien A R, Logan, Nicola, Scott, Sam, Hughes, Ellen C, Harvey, William T, Orton, Richard, Thomson, Emma C, Gunson, Rory N, Viana, Mafalda, Willett, Brian, Murcia, Pablo R
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 28.12.2022
• Subjects: Antibodies; Antibodies, Neutralizing; Antibodies, Viral; Antigenicity; Coronaviruses; COVID-19; Disease transmission; Herd immunity; Humans; Immunology; Major; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Vaccination; SARS-CoV-2; immunological history; virus neutralization; antibody-mediated immunity; virus evolution

Abstract Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans have been exposed to distinct SARS-CoV-2 antigens, either by infection with different variants, and/or vaccination. Population immunity is thus highly heterogeneous, but the impact of such heterogene...