Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription

• Published in: Journal of molecular biology Vol. 436; no. 7; p. 168376
• Main Authors: Konuma, Tsuyoshi, Zhou, Ming-Ming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2024
• Subjects: Acetylation; chromatin; Chromatin - genetics; Chromatin - metabolism; chromatin biology; gene transcription; genes; histone code; histone modifications; histones; Histones - genetics; Histones - metabolism; lysine; Lysine - genetics; Lysine - metabolism; methylation; molecular biology; Protein Domains; transcription (genetics); Transcription, Genetic; Transcriptional Activation; chromatin biology; gene transcription; histone modifications

A three-phase traffic light system model showing that histone H3K27me3 marks for transcriptional silencing, H3K27cr for transcriptional repression, and H3K27ac for transcriptional activation, respectively. [Display omitted] •Site-specific histone modifications direct gene transcription in chromatin....