NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

• Published in: The Journal of biological chemistry Vol. 299; no. 8; p. 104975
• Main Authors: Myakala, Komuraiah, Wang, Xiaoxin X., Shults, Nataliia V., Krawczyk, Ewa, Jones, Bryce A., Yang, Xiaoping, Rosenberg, Avi Z., Ginley, Brandon, Sarder, Pinaki, Brodsky, Leonid, Jang, Yura, Na, Chan Hyun, Qi, Yue, Zhang, Xu, Guha, Udayan, Wu, Ci, Bansal, Shivani, Ma, Junfeng, Cheema, Amrita, Albanese, Chris, Hirschey, Matthew D., Yoshida, Teruhiko, Kopp, Jeffrey B., Panov, Julia, Levi, Moshe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Type 2 - metabolism; Diabetic Nephropathies - metabolism; DNA, Mitochondrial - metabolism; Inflammation - metabolism; Interferons - metabolism; Mice; Mitochondria - metabolism; NAD - metabolism; Nucleotidyltransferases - metabolism; ▪; GLP-1; NR; SGLT2; ▪; TBARS; KIM-1; NAD; ARB; 4-HNE; FAO; ACEI; STING; cGAS-STING; DKD; diabetic kidney disease; mitochondrial DNA damage; mitochondria; sirtuin 3; inflammation, diabetes

Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United -States. Despite the beneficial interventions available for patients with diabetes, there remains a need for additional therapeutic targets and therapies in diabetic kidney disease (DKD). Inflammation and oxidat...