VDR downregulation and promoter hypermethylation as one of the causes for triggering type 2 diabetes mellitus: Clinical and molecular studies

• Published in: Journal of diabetes and metabolic disorders Vol. 22; no. 2; pp. 1443 - 1451
• Main Authors: Tarfeen, Najeebul, Masoodi, Shariq Rashid, Nisa, Khair Ul, Ali, Shafat, Ahmad, Mir Bilal, Ganai, Bashir Ahmad
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 29.07.2023; BioMed Central Ltd
• Subjects: Alfacalcidol; Calcifediol; Diabetes; Diabetics; Endocrinology; Gene expression; Genes; Leptin; Medicine; Medicine & Public Health; Metabolic Diseases; Methylation; Research Article; Tumor necrosis factor; Type 2 diabetes; Vitamin D; Illinois; Inflammatory biomarkers; Promoter methylation; Vitamin D; VDR; Diabetes mellitus

Background Our present study was to investigate the methylation and Gene expression of the vitamin D receptor (VDR) gene in the causing T2DM and to determine the inflammatory biomarkers in exaggerating T2DM in Kashmiri population. Methods In this study, T2DM cases ( n  = 100) and controls ( n  = 100...