The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

• Published in: The Journal of cell biology Vol. 195; no. 2; pp. 231 - 243
• Main Authors: Brownlee, Christopher W, Klebba, Joey E, Buster, Daniel W, Rogers, Gregory C
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 17.10.2011
• Subjects: Animals; Cell Cycle; Cell Line; Centrioles; Drosophila; Drosophila Proteins - physiology; Mitosis; Phosphorylation; Protein Phosphatase 2 - physiology; Protein Stability; Protein Subunits; Protein-Serine-Threonine Kinases - metabolism; Protein-Serine-Threonine Kinases - physiology

Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis. Plk4 (Polo-like kinase 4) activity initiates centriole duplication and is regulated by ubiquitin-mediated proteolysis. Throughou...