Low urinary citrate excretion in nephrolithiasis

The urinary citrate excretion was examined in patients with nephrolithiasis who were categorized on the basis of different physiologic or metabolic abnormalities. A wide prevalence of low citrate excretion (hypocitraturia) was observed, with over one half of our patients with stones exhibiting it. H...

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Published inUrology (Ridgewood, N.J.) Vol. 21; no. 1; pp. 8 - 14
Main Authors Nicar, Michael J., Skurla, Carolyn, Sakhaee, Khashayar, Pak, Charles Y.C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1983
Subjects
Acidosis, Renal Tubular - urine
Adult
Calcium - urine
Citrates - urine
Citric Acid
Female
Humans
Kidney - physiopathology
Kidney Calculi - physiopathology
Kidney Calculi - urine
Male
Menopause
Middle Aged
Oxalates - urine
Sex Factors
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ISSN0090-4295
1527-9995
DOI10.1016/0090-4295(83)90113-9

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Summary:The urinary citrate excretion was examined in patients with nephrolithiasis who were categorized on the basis of different physiologic or metabolic abnormalities. A wide prevalence of low citrate excretion (hypocitraturia) was observed, with over one half of our patients with stones exhibiting it. Hypocitraturia was found in all patient categories except primary hyperparathyroidism and hyperuricosuric calcium oxalate nephrolithiasis. As expected, hypocitraturia was present in renal tubular acidosis and in enteric hyperoxaluria. However, urinary citrate was also low in absorptive and renal hypercalciurias, and in patients in whom an acid-base disturbance was clearly excluded.
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ISSN:0090-4295
1527-9995
DOI:10.1016/0090-4295(83)90113-9