MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells

• Published in: Human molecular genetics Vol. 21; no. 10; pp. 2157 - 2165
• Main Authors: ALVAREZ-DIAZ, Silvia, VALLE, Noelia, FERRER-MAYORGA, Gemma, LOMBARDIA, Luis, HERRERA, Mercedes, DOMINGUEZ, Orlando, SEGURA, Miguel F, BONILLA, Félix, HERNANDO, Eva, MUNOZ, Alberto
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.05.2012
• Subjects: Biological and medical sciences; Calcitriol - pharmacology; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms - genetics; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Genetics of eukaryotes. Biological and molecular evolution; HCT116 Cells; Humans; Medical sciences; MicroRNAs - biosynthesis; MicroRNAs - pharmacology; Molecular and cellular biology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Antineoplastic agent; RNA interference; Micro RNA; Malignant tumor; Colonic disease; Gene silencing; Colon cancer; Gene; Vitamin D; Digestive diseases; Intestinal disease; Genetics; Tumor cell; Cancer

Vitamin D deficiency is associated with the high risk of colon cancer and a variety of other diseases. The active vitamin D metabolite 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) regulates gene transcription via its nuclear receptor (VDR), and posttranscriptional regulatory mechanisms of gene expr...