Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

• Published in: Pharmacology & therapeutics (Oxford) Vol. 129; no. 2; pp. 120 - 148
• Main Authors: Leopoldo, Marcello, Lacivita, Enza, Berardi, Francesco, Perrone, Roberto, Hedlund, Peter B.
• Format: Journal Article
• Language: English
• Published: England 01.02.2011
• Subjects: agonists; Animals; antagonists; blood serum; brain; Central Nervous System Diseases - drug therapy; Central Nervous System Diseases - metabolism; cognition; etiology; genes; Humans; intestinal mucosa; Ligands; Mice; nervous system diseases; Receptors, Serotonin - metabolism; serotonin; Serotonin Agents - chemistry; Serotonin Agents - metabolism; Serotonin Agents - therapeutic use; Structure-Activity Relationship; structure-activity relationships

Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the central nervous system, serotonin (5-HT) has been shown to be involved in virtually all cognitive and behavioral human functions, and alterations in its neurochemistry have been implicated in the etiology of a ple...