Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 16; pp. 4992 - 5002
• Main Authors: Huang, Qiang, Tan, Yexiong, Yin, Peiyuan, Ye, Guozhu, Gao, Peng, Lu, Xin, Wang, Hongyang, Xu, Guowang
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.08.2013
• Subjects: Adult; Aged; Antineoplastic agents; Antioxidants - metabolism; Betaine - metabolism; Biological and medical sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carnitine - analogs & derivatives; Carnitine - genetics; Carnitine - metabolism; Citric Acid Cycle; Fatty Acid Desaturases - genetics; Fatty Acid Desaturases - metabolism; Fatty Acids, Unsaturated - genetics; Fatty Acids, Unsaturated - metabolism; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gluconeogenesis; Glutathione - genetics; Glutathione - metabolism; Glycolysis; Hepatitis, Chronic - genetics; Hepatitis, Chronic - metabolism; Humans; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolome - genetics; Metabolomics - methods; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Pharmacology. Drug treatments; Phospholipases A2 - genetics; Phospholipases A2 - metabolism; Tumors; Liver cancer; Metabolomics; Metabonomics; Digestive diseases; Hepatic disease; Hepatocellular carcinoma; Malignant tumor; Pharmacokinetics; Metabolism; Cancer

Hepatocellular carcinoma has a poor prognosis due to its rapid development and early metastasis. In this report, we characterized the metabolic features of hepatocellular carcinoma using a nontargeted metabolic profiling strategy based on liquid chromatography-mass spectrometry. Fifty pairs of liver...